Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue

Mathieu Angin, Douglas S. Kwon, Hendrik Streeck, Fang Wen, Melanie King, Ashley Rezai, Kenneth Law, Tomoyuki C. Hongo, Augustine Pyo, Alicja Piechocka-Trocha, Ildiko Toth, Florencia Pereyra, Musie Ghebremichael, Scott J. Rodig, Danny A. Milner, James M. Richter, Marcus Altfeld, Daniel E. Kaufmann, Bruce D. Walker, Marylyn M. Addo

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.

Original languageEnglish
Pages (from-to)1495-1500
Number of pages6
JournalJournal of Infectious Diseases
Volume205
Issue number10
DOIs
StatePublished - 15 May 2012
Externally publishedYes

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