TY - JOUR
T1 - Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B
AU - Xuan, Zhao
AU - Barthet, Gael
AU - Shioi, Junichi
AU - Xu, Jindong
AU - Georgakopoulos, Anastasios
AU - Bruban, Julien
AU - Robakis, Nikolaos K.
PY - 2013/10/18
Y1 - 2013/10/18
N2 - Background: Presenilin-1/γ-secretase is critical to neuronal function. Results: Inhibition of presenilin-1/γ-secretase increases release of glutamate, stimulatingNMDARand calpain while decreasing phosphorylation and surface expression of neuronal GluN2B. Conclusion: Presenilin-1/γ-secretase regulates glutamate release,NMDAR- dependentcalpain activity, and modification of GluN2B. Significance: This study reveals a role for γ-secretase in release of glutamate, a neurotransmitter central to neuronal function, and excitotoxicity, a stress important to neurodegeneration.
AB - Background: Presenilin-1/γ-secretase is critical to neuronal function. Results: Inhibition of presenilin-1/γ-secretase increases release of glutamate, stimulatingNMDARand calpain while decreasing phosphorylation and surface expression of neuronal GluN2B. Conclusion: Presenilin-1/γ-secretase regulates glutamate release,NMDAR- dependentcalpain activity, and modification of GluN2B. Significance: This study reveals a role for γ-secretase in release of glutamate, a neurotransmitter central to neuronal function, and excitotoxicity, a stress important to neurodegeneration.
UR - http://www.scopus.com/inward/record.url?scp=84886880952&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.499004
DO - 10.1074/jbc.M113.499004
M3 - Article
C2 - 24025330
AN - SCOPUS:84886880952
SN - 0021-9258
VL - 288
SP - 30495
EP - 30501
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 42
ER -