TY - JOUR
T1 - Prepubertal acrylamide exposure causes dose-response decreases in spermatic production and functionality with modulation of genes involved in the spermatogenesis in rats
AU - Ivanski, Fernanda
AU - de Oliveira, Viviane Matoso
AU - de Oliveira, Isabela Medeiros
AU - de Araújo Ramos, Anderson Tadeu
AU - de Oliveira Tonete, Selma Thaisa
AU - de Oliveira Hykavei, Gabriel
AU - Bargi-Souza, Paula
AU - Schiessel, Dalton Luiz
AU - Martino-Andrade, Anderson Joel
AU - Romano, Marco Aurelio
AU - Marino Romano, Renata
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/4/30
Y1 - 2020/4/30
N2 - The increase in human infertility prevalence due to male reproductive disorders has been associated with extensive endocrine-disrupting chemical (EDC) exposure. Acrylamide (AA) is a compound formed spontaneously during heat processing of some foods that are mainly consumed by children and adolescents. In this study, we evaluated the prepubertal AA exposure effects on male adult reproductive physiology using a prepubertal experimental model to analyze the pubertal development, spermatogenesis hormones levels and genes expression involved in male reproductive function. This study is the first one to use the validated protocol to correlate the AA exposure with puberty development, as well as the AA-induced endocrine disrupting effects on reproductive axis. AA did not affect the age at puberty, the reproductive organ's weight and serum hormonal levels. AA reduces spermatogenesis, induces morphological and functional defects on sperm and alters transcript expression of sexual hormone receptors (Ar and Esr2), the transcript expression of Tnf, Egr2, Rhcg and Lrrc34. These findings suggest that excessive AA consumption may impair their reproductive capacity at adulthood, despite no changes in hormonal profile being observed.
AB - The increase in human infertility prevalence due to male reproductive disorders has been associated with extensive endocrine-disrupting chemical (EDC) exposure. Acrylamide (AA) is a compound formed spontaneously during heat processing of some foods that are mainly consumed by children and adolescents. In this study, we evaluated the prepubertal AA exposure effects on male adult reproductive physiology using a prepubertal experimental model to analyze the pubertal development, spermatogenesis hormones levels and genes expression involved in male reproductive function. This study is the first one to use the validated protocol to correlate the AA exposure with puberty development, as well as the AA-induced endocrine disrupting effects on reproductive axis. AA did not affect the age at puberty, the reproductive organ's weight and serum hormonal levels. AA reduces spermatogenesis, induces morphological and functional defects on sperm and alters transcript expression of sexual hormone receptors (Ar and Esr2), the transcript expression of Tnf, Egr2, Rhcg and Lrrc34. These findings suggest that excessive AA consumption may impair their reproductive capacity at adulthood, despite no changes in hormonal profile being observed.
KW - Acrylamide
KW - Developmental origin of health and disease (DOHaD)
KW - Endocrine-disrupting chemical
KW - Male reproductive system
KW - Spermatogenesis
KW - Toxicology
UR - https://www.scopus.com/pages/publications/85080997401
U2 - 10.1016/j.tox.2020.152428
DO - 10.1016/j.tox.2020.152428
M3 - Article
C2 - 32151602
AN - SCOPUS:85080997401
SN - 0300-483X
VL - 436
JO - Toxicology
JF - Toxicology
M1 - 152428
ER -