Preparation of 4-methyl-5-(β-hydroxyethyl)-thiazole

Peng Wang; Fei Xin; Hai Hua Li; Xi Ying Du

Preparation of 4-methyl-5-(β-hydroxyethyl)-thiazole

Peng Wang, Fei Xin, Hai Hua Li, Xi Ying Du

Research output: Contribution to journal › Article › peer-review

Abstract

4-methyl-5-(β-hydroxyethyl)-thiazole was prepared, starting from α-acetobutyro-lactone, by chlorination, hydrolysis and decarboxylation, cyclization, diazotization and reduction. The yield of diazotization and reduction was remarkably increased and the procedure was simplified by the use of H₂SO₄ in place of HCl, thus avoiding the formation of the by-product 2-chloro-4-methyl-5-(β-hydroxyethyl)-thiazole, and finished the preparation of the object product in a one pot process. The total yield reached 70%.

Original language	English
Pages (from-to)	821-824
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	24
Issue number	9
State	Published - Sep 2004
Externally published	Yes

Keywords

2-amidocyanogen-4-methyl-5-(β-hydroxyethyl)-thiazole
4-methyl-5-(β-hydroxyethyl)-thiazole
Diazotization
One pot process
α-acetobutyrolact-one

Cite this

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title = "Preparation of 4-methyl-5-(β-hydroxyethyl)-thiazole",

abstract = "4-methyl-5-(β-hydroxyethyl)-thiazole was prepared, starting from α-acetobutyro-lactone, by chlorination, hydrolysis and decarboxylation, cyclization, diazotization and reduction. The yield of diazotization and reduction was remarkably increased and the procedure was simplified by the use of H2SO4 in place of HCl, thus avoiding the formation of the by-product 2-chloro-4-methyl-5-(β-hydroxyethyl)-thiazole, and finished the preparation of the object product in a one pot process. The total yield reached 70\%.",

keywords = "2-amidocyanogen-4-methyl-5-(β-hydroxyethyl)-thiazole, 4-methyl-5-(β-hydroxyethyl)-thiazole, Diazotization, One pot process, α-acetobutyrolact-one",

author = "Peng Wang and Fei Xin and Li, \{Hai Hua\} and Du, \{Xi Ying\}",

year = "2004",

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language = "English",

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pages = "821--824",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

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TY - JOUR

T1 - Preparation of 4-methyl-5-(β-hydroxyethyl)-thiazole

AU - Wang, Peng

AU - Xin, Fei

AU - Li, Hai Hua

AU - Du, Xi Ying

PY - 2004/9

Y1 - 2004/9

N2 - 4-methyl-5-(β-hydroxyethyl)-thiazole was prepared, starting from α-acetobutyro-lactone, by chlorination, hydrolysis and decarboxylation, cyclization, diazotization and reduction. The yield of diazotization and reduction was remarkably increased and the procedure was simplified by the use of H2SO4 in place of HCl, thus avoiding the formation of the by-product 2-chloro-4-methyl-5-(β-hydroxyethyl)-thiazole, and finished the preparation of the object product in a one pot process. The total yield reached 70%.

AB - 4-methyl-5-(β-hydroxyethyl)-thiazole was prepared, starting from α-acetobutyro-lactone, by chlorination, hydrolysis and decarboxylation, cyclization, diazotization and reduction. The yield of diazotization and reduction was remarkably increased and the procedure was simplified by the use of H2SO4 in place of HCl, thus avoiding the formation of the by-product 2-chloro-4-methyl-5-(β-hydroxyethyl)-thiazole, and finished the preparation of the object product in a one pot process. The total yield reached 70%.

KW - 2-amidocyanogen-4-methyl-5-(β-hydroxyethyl)-thiazole

KW - 4-methyl-5-(β-hydroxyethyl)-thiazole

KW - Diazotization

KW - One pot process

KW - α-acetobutyrolact-one

UR - https://www.scopus.com/pages/publications/11444263298

M3 - Article

AN - SCOPUS:11444263298

SN - 1001-0645

VL - 24

SP - 821

EP - 824

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 9

ER -

Preparation of 4-methyl-5-(β-hydroxyethyl)-thiazole

Abstract

Keywords

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