Preparation of 4-methyl-5-(β-hydroxyethyl)-thiazole

Peng Wang, Fei Xin, Hai Hua Li, Xi Ying Du

Research output: Contribution to journalArticlepeer-review

Abstract

4-methyl-5-(β-hydroxyethyl)-thiazole was prepared, starting from α-acetobutyro-lactone, by chlorination, hydrolysis and decarboxylation, cyclization, diazotization and reduction. The yield of diazotization and reduction was remarkably increased and the procedure was simplified by the use of H2SO4 in place of HCl, thus avoiding the formation of the by-product 2-chloro-4-methyl-5-(β-hydroxyethyl)-thiazole, and finished the preparation of the object product in a one pot process. The total yield reached 70%.

Original languageEnglish
Pages (from-to)821-824
Number of pages4
JournalBeijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume24
Issue number9
StatePublished - Sep 2004
Externally publishedYes

Keywords

  • 2-amidocyanogen-4-methyl-5-(β-hydroxyethyl)-thiazole
  • 4-methyl-5-(β-hydroxyethyl)-thiazole
  • Diazotization
  • One pot process
  • α-acetobutyrolact-one

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