Preoperative Laboratory Values Are Predictive of Adverse Postoperative Outcomes in Patients Older Than 65 Years Undergoing Brain Tumor Resection: A National Surgical Quality Improvement Program Study

Objective: In this study, we used a large national database to assess the effect of preoperative laboratory value (PLV) derangements on postoperative outcomes in patients older than 65 years undergoing brain tumor resection. Methods: Data was collected for patients >65 years old undergoing brain tumor resection from 2015 to 2019 (N = 10,525). Univariate and multivariate analysis were performed for 11 PLVs and 6 postoperative outcomes. Results: Hypernatremia (odds ratio [OR], 4.707; 95% confidence interval [CI], 1.695–13.071; P < 0.01) and increased creatinine level (OR, 2.556; 95% CI, 1.291–5.060; P < 0.01) were the most significant predictors of 30-day mortality. The most significant predictor of Clavien-Dindo grade IV complications was increased creatinine level (OR, 1.667; 95% CI, 1.064–2.613; P < 0.05), whereas, significant predictors of major complications were hypoalbuminemia (OR, 1.426; 95% CI, 1.132–1.796; P < 0.05) and leukocytosis (OR, 1.347; 95% CI, 1.075–1.688; P < 0.05). Predictors of readmission were anemia (OR, 1.326; 95% CI, 1.047–1.680; P < 0.05) and thrombocytopenia (OR, 1.387; 95% CI, 1.037–1.856; P < 0.05), whereas, hypoalbuminemia (OR, 1.787; 95% CI, 1.280–2.495; P < 0.001) was predictive of reoperation. Increased partial thromboplastin time and hypoalbuminemia were predictors of extended length of stay (OR, 2.283, 95% CI, 1.360–3.834, P < 0.01 and OR, 1.553, 95% CI, 1.553–1.966, P < 0.001, respectively). Hypernatremia (OR, 2.115; 95% CI, 1.181–3.788; P < 0.05) and hypoalbuminemia (OR, 1.472; 95% CI, 1.239–1.748; P < 0.001) were the most significant predictors of NHD. Seven of 11 PLVs were associated with adverse postoperative outcomes. Conclusions: PLV derangements were significantly associated with adverse postoperative outcomes in patients older than 65 years undergoing brain tumor resection. The most significant predictors of adverse postoperative outcomes were hypoalbuminemia and leukocytosis.