TY - JOUR
T1 - Prenatal salivary sex hormone levels and birth-weight-for-gestational age
AU - Svensson, Katherine
AU - Just, Allan C.
AU - Fleisch, Abby F.
AU - Sanders, Alison P.
AU - Tamayo-Ortiz, Marcela
AU - Baccarelli, Andrea A.
AU - Wright, Rosalind J.
AU - Téllez-Rojo, Martha M.
AU - Wright, Robert O.
AU - Burris, Heather H.
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Objective: To determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age. Study design: We measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status. Results: In total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: −0.27 to −0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13–1.99). Conclusion: Higher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.
AB - Objective: To determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age. Study design: We measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status. Results: In total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: −0.27 to −0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13–1.99). Conclusion: Higher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.
UR - http://www.scopus.com/inward/record.url?scp=85066062562&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0385-y
DO - 10.1038/s41372-019-0385-y
M3 - Article
C2 - 31110244
AN - SCOPUS:85066062562
SN - 0743-8346
VL - 39
SP - 941
EP - 948
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 7
ER -