TY - JOUR
T1 - Prenatal salivary sex hormone levels and birth-weight-for-gestational age
AU - Svensson, Katherine
AU - Just, Allan C.
AU - Fleisch, Abby F.
AU - Sanders, Alison P.
AU - Tamayo-Ortiz, Marcela
AU - Baccarelli, Andrea A.
AU - Wright, Rosalind J.
AU - Téllez-Rojo, Martha M.
AU - Wright, Robert O.
AU - Burris, Heather H.
N1 - Funding Information:
Acknowledgements This work was supported by NIH grants R01 ES014930, R01 ES026033, R01 ES021357, R24 ES028522, R01 ES013744, R01 ES023450, P30 ES023515, K99ES027508, K23ES024803, and K23ES022242. Co-investigators and staff at the INSP were also supported and received partial funding from the National Institute of Public Health/Ministry of Health of Mexico. We acknowledge Dr. Clemens Kirschbaum for performing the steroid hormone panel on the saliva samples. We acknowledge the American British Cowdray Medical Center for providing research facilities, which made it possible to conduct the study.
Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Objective: To determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age. Study design: We measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status. Results: In total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: −0.27 to −0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13–1.99). Conclusion: Higher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.
AB - Objective: To determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age. Study design: We measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status. Results: In total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: −0.27 to −0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13–1.99). Conclusion: Higher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.
UR - http://www.scopus.com/inward/record.url?scp=85066062562&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0385-y
DO - 10.1038/s41372-019-0385-y
M3 - Article
C2 - 31110244
AN - SCOPUS:85066062562
SN - 0743-8346
VL - 39
SP - 941
EP - 948
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 7
ER -