@article{a7b38a9a8c7f47adab3a73e03007b63c,
title = "Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry",
abstract = "Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5 exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.",
keywords = "Air pollution, Bioenergetics, Mitochondria, Pregnancy",
author = "Brunst, {Kelly J.} and Hsu, {Hsiao Hsien Leon} and Li Zhang and Xiang Zhang and Carroll, {Kecia N.} and Allan Just and Coull, {Brent A.} and Itai Kloog and Wright, {Robert O.} and Baccarelli, {Andrea A.} and Wright, {Rosalind J.}",
note = "Funding Information: We would like to thank the participants of the PRISM cohort and our funding agencies. Specifically, this work was supported by the National Heart, Lung, and Blood Institute under grants R01HL095606 (RJ Wright) and R01HL114396 (RJ Wright); the National Institute of Environmental Health Sciences (NIEHS) under grants R00ES024116 (KJ Brunst), P30ES006096 (KJ Brunst), and P30ES023515 (RJ Wright); derivation of air pollution exposure estimates was supported by UG3/UH3 OD023337 (RJ Wright). Biobanking infrastructure was supported by the Mount Sinai Health System Clinical Translational Science Award from the National Center for Advancing Translational Sciences under grant UL1 TR001433 (RJ Wright). Publisher Copyright: {\textcopyright} 2021",
year = "2022",
month = jan,
doi = "10.1016/j.mito.2021.11.003",
language = "English",
volume = "62",
pages = "102--110",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",
}