TY - JOUR
T1 - Prenatal exposure to multiple organochlorine compounds and childhood body mass index
AU - Colicino, Elena
AU - Margetaki, Katerina
AU - Valvi, Damaskini
AU - Pedretti, Nicolo Foppa
AU - Stratakis, Nikos
AU - Vafeiadi, Marina
AU - Roumeliotaki, Theano
AU - Kyrtopoulos, Soterios A.
AU - Kiviranta, Hannu
AU - Stephanou, Euripides G.
AU - Kogevinas, Manolis
AU - McConnell, Rob
AU - Berhane, Kiros T.
AU - Chatzi, Leda
AU - Conti, David V.
N1 - Funding Information:
During the preparation of this manuscript, E.C. was supported by the National Institute of Environmental Health Science (NIEHS): R01ES032242, 5U2CES026555-03 and P30ES023515. D.V. was supported by P30ES023515 and R21ES029328. D.V.C. was supported by P01CA196569. L.C. was supported by NIEHS (R21ES029681, R01ES030691, R01ES029944, R01ES030364, R21ES028903, and P30ES007048). N.S. has received funding from the Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S) and from IJC2020-043630-I financed by MCIN/AEI/10.13039/501100011033 and the European Union “NextGenerationEU/PRTR”.
Publisher Copyright:
© 2022 Wolters Kluwer Health. All rights reserved.
PY - 2022/6/22
Y1 - 2022/6/22
N2 - Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.
AB - Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.
KW - Bayesian varying coefficient kernel machine regressions
KW - Bayesian weighted quantile sum regressions
KW - Body mass index
KW - Chemical mixture
KW - Organochlorine compounds
KW - Outcome trajectories
UR - http://www.scopus.com/inward/record.url?scp=85129975488&partnerID=8YFLogxK
U2 - 10.1097/EE9.0000000000000201
DO - 10.1097/EE9.0000000000000201
M3 - Article
AN - SCOPUS:85129975488
SN - 2474-7882
VL - 6
SP - E201
JO - Environmental Epidemiology
JF - Environmental Epidemiology
IS - 3
ER -