Prenatal exposure to multiple organochlorine compounds and childhood body mass index

Elena Colicino; Katerina Margetaki; Damaskini Valvi; Nicolo Foppa Pedretti; Nikos Stratakis; Marina Vafeiadi; Theano Roumeliotaki; Soterios A. Kyrtopoulos; Hannu Kiviranta; Euripides G. Stephanou; Manolis Kogevinas; Rob McConnell; Kiros T. Berhane; Leda Chatzi; David V. Conti

doi:10.1097/EE9.0000000000000201

Prenatal exposure to multiple organochlorine compounds and childhood body mass index

Elena Colicino, Katerina Margetaki, Damaskini Valvi, Nicolo Foppa Pedretti, Nikos Stratakis, Marina Vafeiadi, Theano Roumeliotaki, Soterios A. Kyrtopoulos, Hannu Kiviranta, Euripides G. Stephanou, Manolis Kogevinas, Rob McConnell, Kiros T. Berhane, Leda Chatzi, David V. Conti

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Abstract

Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.

Original language	English
Pages (from-to)	E201
Journal	Environmental Epidemiology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1097/EE9.0000000000000201
State	Published - 22 Jun 2022

Keywords

Bayesian varying coefficient kernel machine regressions
Bayesian weighted quantile sum regressions
Body mass index
Chemical mixture
Organochlorine compounds
Outcome trajectories

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10.1097/EE9.0000000000000201

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Colicino, E., Margetaki, K., Valvi, D., Pedretti, N. F., Stratakis, N., Vafeiadi, M., Roumeliotaki, T., Kyrtopoulos, S. A., Kiviranta, H., Stephanou, E. G., Kogevinas, M., McConnell, R., Berhane, K. T., Chatzi, L., & Conti, D. V. (2022). Prenatal exposure to multiple organochlorine compounds and childhood body mass index. Environmental Epidemiology, 6(3), E201. https://doi.org/10.1097/EE9.0000000000000201

@article{fd79892cdc4c4ce8a915d397e119bb3f,

title = "Prenatal exposure to multiple organochlorine compounds and childhood body mass index",

abstract = "Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.",

keywords = "Bayesian varying coefficient kernel machine regressions, Bayesian weighted quantile sum regressions, Body mass index, Chemical mixture, Organochlorine compounds, Outcome trajectories",

author = "Elena Colicino and Katerina Margetaki and Damaskini Valvi and Pedretti, {Nicolo Foppa} and Nikos Stratakis and Marina Vafeiadi and Theano Roumeliotaki and Kyrtopoulos, {Soterios A.} and Hannu Kiviranta and Stephanou, {Euripides G.} and Manolis Kogevinas and Rob McConnell and Berhane, {Kiros T.} and Leda Chatzi and Conti, {David V.}",

year = "2022",

month = jun,

day = "22",

doi = "10.1097/EE9.0000000000000201",

language = "English",

volume = "6",

pages = "E201",

journal = "Environmental Epidemiology",

issn = "2474-7882",

publisher = "Wolters Kluwer Health",

number = "3",

}

Colicino, E, Margetaki, K, Valvi, D, Pedretti, NF, Stratakis, N, Vafeiadi, M, Roumeliotaki, T, Kyrtopoulos, SA, Kiviranta, H, Stephanou, EG, Kogevinas, M, McConnell, R, Berhane, KT, Chatzi, L & Conti, DV 2022, 'Prenatal exposure to multiple organochlorine compounds and childhood body mass index', Environmental Epidemiology, vol. 6, no. 3, pp. E201. https://doi.org/10.1097/EE9.0000000000000201

TY - JOUR

T1 - Prenatal exposure to multiple organochlorine compounds and childhood body mass index

AU - Colicino, Elena

AU - Margetaki, Katerina

AU - Valvi, Damaskini

AU - Pedretti, Nicolo Foppa

AU - Stratakis, Nikos

AU - Vafeiadi, Marina

AU - Roumeliotaki, Theano

AU - Kyrtopoulos, Soterios A.

AU - Kiviranta, Hannu

AU - Stephanou, Euripides G.

AU - Kogevinas, Manolis

AU - McConnell, Rob

AU - Berhane, Kiros T.

AU - Chatzi, Leda

AU - Conti, David V.

PY - 2022/6/22

Y1 - 2022/6/22

N2 - Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.

AB - Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.

KW - Bayesian varying coefficient kernel machine regressions

KW - Bayesian weighted quantile sum regressions

KW - Body mass index

KW - Chemical mixture

KW - Organochlorine compounds

KW - Outcome trajectories

UR - http://www.scopus.com/inward/record.url?scp=85129975488&partnerID=8YFLogxK

U2 - 10.1097/EE9.0000000000000201

DO - 10.1097/EE9.0000000000000201

M3 - Article

AN - SCOPUS:85129975488

SN - 2474-7882

VL - 6

SP - E201

JO - Environmental Epidemiology

JF - Environmental Epidemiology

IS - 3

ER -

Prenatal exposure to multiple organochlorine compounds and childhood body mass index

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Keywords

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