Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs

Saideep Gona; Alison P. Sanders; Marie Lynn Miranda; Rebecca C. Fry

doi:10.1016/j.gdata.2015.07.001

Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs

Saideep Gona, Alison P. Sanders, Marie Lynn Miranda, Rebecca C. Fry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n. =. 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).

Original language	English
Pages (from-to)	378-380
Number of pages	3
Journal	Genomics Data
Volume	5
DOIs	https://doi.org/10.1016/j.gdata.2015.07.001
State	Published - 1 Sep 2015

Keywords

Cadmium
CpG methylation
Epigenetics
Exposure
Prenatal

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10.1016/j.gdata.2015.07.001

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title = "Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs",

abstract = "A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n. =. 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).",

keywords = "Cadmium, CpG methylation, Epigenetics, Exposure, Prenatal",

author = "Saideep Gona and Sanders, \{Alison P.\} and Miranda, \{Marie Lynn\} and Fry, \{Rebecca C.\}",

note = "Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = sep,

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doi = "10.1016/j.gdata.2015.07.001",

language = "English",

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T1 - Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs

AU - Gona, Saideep

AU - Sanders, Alison P.

AU - Miranda, Marie Lynn

AU - Fry, Rebecca C.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n. =. 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).

AB - A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n. =. 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).

KW - Cadmium

KW - CpG methylation

KW - Epigenetics

KW - Exposure

KW - Prenatal

UR - https://www.scopus.com/pages/publications/84937875747

U2 - 10.1016/j.gdata.2015.07.001

DO - 10.1016/j.gdata.2015.07.001

M3 - Article

AN - SCOPUS:84937875747

SN - 2213-5960

VL - 5

SP - 378

EP - 380

JO - Genomics Data

JF - Genomics Data

ER -

Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs

Abstract

Keywords

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