Prenatal diagnosis of hemophilia A by DNA analysis

Prenatal diagnosis of hemophilia A and B was carried out in our hospital by DNA analysis in early and late villi and amniotic cells. Fifteen women with family history of hemophilia were studied by different sets of DNA probes and restrictive enzymes from Nov. 1986 to March 1989. Two of the 15 women were proved not carriers by blood sample assaying. Two did not show sites of polymorphism and another was not reported owing too small a DNA sample of amniotic cells. Among other 10 cases, 4 were proven normal male fetus, 1 proven affected male fetus was induced, and 5 were proven female fetus with 2 carriers.