Prenatal diagnosis and multiple pregnancy

Jane Cleary-Goldman, Mary E. D'Alton, Richard L. Berkowitz

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

The incidence of twins, triplets, and high-order multiples has increased dramatically in the last two decades secondary to greater reliance on fertility treatments and to delayed childbearing. Offspring of a multiple gestation are at increased risk for both chromosomal and structural abnormalities. Prenatal diagnosis in these patients is challenging. Options for screening tests are limited. Invasive diagnostic procedures are complex. Likewise, physicians and patients may be faced with the dilemma of deciding how to manage discordant results. The following paper will review the unique concerns associated with prenatal diagnosis in a multiple pregnancy and the current methods of prenatal screening in these patients. Invasive prenatal diagnosis will also be explored.

Original languageEnglish
Pages (from-to)312-320
Number of pages9
JournalSeminars in Perinatology
Volume29
Issue number5
DOIs
StatePublished - Oct 2005
Externally publishedYes

Keywords

  • Amniocentesis
  • Aneuploidy risk
  • Chorionic villus sampling
  • Multiple gestations
  • Nuchal translucency
  • Screening

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