Prenatal chromosome analysis

Fredrica Lisgar; Melvin Gertner; Sheldon Cherry; Lillian Y. Hsu; Kurt Hirschhorn

doi:10.1038/225280a0

Prenatal chromosome analysis

Fredrica Lisgar
, Melvin Gertner
, Sheldon Cherry
, Lillian Y. Hsu
, Kurt Hirschhorn

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid^1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.¹, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.

Original language	English
Pages (from-to)	280-281
Number of pages	2
Journal	Nature
Volume	225
Issue number	5229
DOIs	https://doi.org/10.1038/225280a0
State	Published - 1970

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title = "Prenatal chromosome analysis",

abstract = "CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.",

author = "Fredrica Lisgar and Melvin Gertner and Sheldon Cherry and Hsu, \{Lillian Y.\} and Kurt Hirschhorn",

year = "1970",

doi = "10.1038/225280a0",

language = "English",

volume = "225",

pages = "280--281",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5229",

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T1 - Prenatal chromosome analysis

AU - Lisgar, Fredrica

AU - Gertner, Melvin

AU - Cherry, Sheldon

AU - Hsu, Lillian Y.

AU - Hirschhorn, Kurt

PY - 1970

Y1 - 1970

N2 - CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.

AB - CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.

UR - https://www.scopus.com/pages/publications/0014952353

U2 - 10.1038/225280a0

DO - 10.1038/225280a0

M3 - Article

C2 - 5460615

AN - SCOPUS:0014952353

SN - 0028-0836

VL - 225

SP - 280

EP - 281

JO - Nature

JF - Nature

IS - 5229

ER -

Prenatal chromosome analysis

Abstract

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