Prenatal chromosome analysis

Fredrica Lisgar; Melvin Gertner; Sheldon Cherry; Lillian Y. Hsu; Kurt Hirschhorn

doi:10.1038/225280a0

Prenatal chromosome analysis

Fredrica Lisgar, Melvin Gertner, Sheldon Cherry, Lillian Y. Hsu, Kurt Hirschhorn

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18 Scopus citations

Abstract

CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid^1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.¹, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.

Original language	English
Pages (from-to)	280-281
Number of pages	2
Journal	Nature
Volume	225
Issue number	5229
DOIs	https://doi.org/10.1038/225280a0
State	Published - 1970

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title = "Prenatal chromosome analysis",

abstract = "CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.",

author = "Fredrica Lisgar and Melvin Gertner and Sheldon Cherry and Hsu, {Lillian Y.} and Kurt Hirschhorn",

year = "1970",

doi = "10.1038/225280a0",

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journal = "Nature",

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T1 - Prenatal chromosome analysis

AU - Lisgar, Fredrica

AU - Gertner, Melvin

AU - Cherry, Sheldon

AU - Hsu, Lillian Y.

AU - Hirschhorn, Kurt

PY - 1970

Y1 - 1970

N2 - CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.

AB - CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1-3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.

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Prenatal chromosome analysis

Abstract

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