TY - JOUR
T1 - Prenatal arsenic exposure and birth outcomes among a population residing near a mining-related superfund site
AU - Claus Henn, Birgit
AU - Ettinger, Adrienne S.
AU - Hopkins, Marianne R.
AU - Jim, Rebecca
AU - Amarasiriwardena, Chitra
AU - Christiani, David C.
AU - Coull, Brent A.
AU - Bellinger, David C.
AU - Wright, Robert O.
N1 - Funding Information:
The research described in this paper was funded in part by the National Institute of Environmental Health Sciences/National Insitutes of Health(NIEHS/NIH) grants P42-ES016454, R01-ES021357, R01-ES014930, R01-ES013744, P30-ES023515, P30-ES000002, and R00-ES022986.
Publisher Copyright:
© 2016, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Background: Limited epidemiologic data exist on prenatal arsenic exposure and fetal growth, particularly in the context of co-exposure to other toxic metals. objective: We examined whether prenatal arsenic exposure predicts birth outcomes among a rural U.S. population, while adjusting for exposure to lead and manganese. Methods: We collected maternal and umbilical cord blood samples at delivery from 622 mother-infant pairs residing near a mining-related Superfund site in Northeast Oklahoma. Whole blood arsenic, lead, and manganese were measured using inductively coupled plasma mass spectrometry. We modeled associations between arsenic concentrations and birth weight, gestational age, head circumference, and birth weight for gestational age. results: Median (25th-75th percentile) maternal and umbilical cord blood metal concentrations, respectively, were as follows: arsenic, 1.4 (1.0-2.3) and 2.4 (1.8-3.3) μg/L; lead, 0.6 (0.4-0.9) and 0.4 (0.3-0.6) μg/dL; manganese, 22.7 (18.8-29.3) and 41.7 (32.2-50.4) μg/L. We estimated negative associations between maternal blood arsenic concentrations and birth outcomes. In multivariable regression models adjusted for lead and manganese, an interquartile range increase in maternal blood arsenic was associated with-77.5 g (95% CI:-127.8,-27.3) birth weight,-0.13 weeks (95% CI:-0.27, 0.01) gestation,-0.22 cm (95% CI:-0.42,-0.03) head circumference, and-0.14 (95% CI:-0.24,-0.04) birth weight for gestational age z-score units. Interactions between arsenic concentrations and lead or manganese were not statistically significant. conclusions: In a population with environmental exposure levels similar to the U.S. general population, maternal blood arsenic was negatively associated with fetal growth. Given the potential for relatively common fetal and early childhood arsenic exposures, our finding that prenatal arsenic can adversely affect birth outcomes is of considerable public health importance.
AB - Background: Limited epidemiologic data exist on prenatal arsenic exposure and fetal growth, particularly in the context of co-exposure to other toxic metals. objective: We examined whether prenatal arsenic exposure predicts birth outcomes among a rural U.S. population, while adjusting for exposure to lead and manganese. Methods: We collected maternal and umbilical cord blood samples at delivery from 622 mother-infant pairs residing near a mining-related Superfund site in Northeast Oklahoma. Whole blood arsenic, lead, and manganese were measured using inductively coupled plasma mass spectrometry. We modeled associations between arsenic concentrations and birth weight, gestational age, head circumference, and birth weight for gestational age. results: Median (25th-75th percentile) maternal and umbilical cord blood metal concentrations, respectively, were as follows: arsenic, 1.4 (1.0-2.3) and 2.4 (1.8-3.3) μg/L; lead, 0.6 (0.4-0.9) and 0.4 (0.3-0.6) μg/dL; manganese, 22.7 (18.8-29.3) and 41.7 (32.2-50.4) μg/L. We estimated negative associations between maternal blood arsenic concentrations and birth outcomes. In multivariable regression models adjusted for lead and manganese, an interquartile range increase in maternal blood arsenic was associated with-77.5 g (95% CI:-127.8,-27.3) birth weight,-0.13 weeks (95% CI:-0.27, 0.01) gestation,-0.22 cm (95% CI:-0.42,-0.03) head circumference, and-0.14 (95% CI:-0.24,-0.04) birth weight for gestational age z-score units. Interactions between arsenic concentrations and lead or manganese were not statistically significant. conclusions: In a population with environmental exposure levels similar to the U.S. general population, maternal blood arsenic was negatively associated with fetal growth. Given the potential for relatively common fetal and early childhood arsenic exposures, our finding that prenatal arsenic can adversely affect birth outcomes is of considerable public health importance.
UR - http://www.scopus.com/inward/record.url?scp=84980324604&partnerID=8YFLogxK
U2 - 10.1289/ehp.1510070
DO - 10.1289/ehp.1510070
M3 - Article
C2 - 26859631
AN - SCOPUS:84980324604
SN - 0091-6765
VL - 124
SP - 1308
EP - 1315
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 8
ER -