Prenatal Δ⁹-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation

Keyphrases

• Striatal 100%
• Δ9-tetrahydrocannabinol (Δ9-THC) 100%
• Epigenetic Dysregulation 100%
• Nucleus Accumbens 80%
• KMT2A 80%
• Major Depressive Disorder 40%
• H3K4me3 40%
• Learned Helplessness 20%
• During Pregnancy 20%
• Drugs of Abuse 20%
• RNA Sequencing (RNA-seq) 20%
• In Vitro Model 20%
• Chromatin 20%
• Dysregulation 20%
• Emotional Processing 20%
• Brain Regions 20%
• Cannabis 20%
• Stress Sensitivity 20%
• Depressive-like Behavior 20%
• Epigenetics 20%
• Neuropsychiatric 20%
• Endophenotype 20%
• Synaptic Plasticity 20%
• Anhedonia 20%
• Transcriptional Profile 20%
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 20%
• Histone H3 20%
• Histone Methyltransferase 20%
• In Utero Exposure 20%
• Vulnerability 20%
• Molecular Signature 20%
• Adult Male 20%
• Reward Processing 20%
• Lysine 20%
• Male Offspring 20%
• Persistent Effects 20%
• Sequence Method 20%
• Transcriptomic Data 20%
• Post-transcriptional Modification 20%
• Epigenetic Signature 20%
• Increased Motivation 20%
• Drugs in Pregnancy 20%
• Rat Offspring 20%
• Activation Model 20%
• Epigenetic Profile 20%
• Prenatal Cannabis Exposure 20%
• Specific Consequences 20%
• Unbiased Sequencing 20%
• Rat Dams 20%

Neuroscience

• Tetrahydrocannabinol 100%
• Nucleus Accumbens 80%
• In Vitro 40%
• Major Depressive Disorder 40%
• Cannabis 40%
• Lysine 40%
• Brain Areas 20%
• Histone 20%
• Transcriptome 20%
• Endophenotype 20%
• Anhedonia 20%
• Synaptic Plasticity 20%
• RNA Sequence 20%
• Histone H3 20%
• Methyltransferase 20%
• Learned Helplessness 20%