TY - JOUR
T1 - Pregnant women’s hepatitis B vaccination coverage in Nigeria
T2 - a national pilot cross-sectional study
AU - Triplex Infection in Pregnancy Collaboration Group
AU - Eleje, George Uchenna
AU - Akaba, Godwin Otuodichinma
AU - Mbachu, Ikechukwu Innocent
AU - Rabiu, Ayyuba
AU - Loto, Olabisi Morebise
AU - Usman, Hadiza Abdullahi
AU - Fiebai, Preye Owen
AU - Chukwuanukwu, Rebecca Chinyelu
AU - Joe-Ikechebelu, Ngozi Nneka
AU - Nwankwo, Chike Henry
AU - Kalu, Stephen Okoroafor
AU - Onubogu, Chinyere Ukamaka
AU - Ogbuagu, Chukwuanugo Nkemakonam
AU - Chukwurah, Shirley Nneka
AU - Uzochukwu, Chinwe Elizabeth
AU - Inuyomi, Samuel Oluwagbenga
AU - Adesoji, Bukola Abimbola
AU - Ogwaluonye, Uchenna Chukwunonso
AU - Nweje, Sussan Ifeyinwa
AU - Egeonu, Richard Obinwanne
AU - Igue, Odion Emmanuel
AU - Jibuaku, Chiamaka Henrietta
AU - Aja, Prince Ogbonnia
AU - Chidozie, Chiamaka Perpetua
AU - Ibrahim, Hadiza Sani
AU - Aliyu, Fatima Ele
AU - Numan, Aisha Ismaila
AU - Okoro, Ogbonna Dennis
AU - Omoruyi, Solace Amechi
AU - Oppah, Ijeoma Chioma
AU - Anyang, Ubong Inyang
AU - Ahmed, Aishat
AU - Umeononihu, Osita Samuel
AU - Umeh, Eric Okechukwu
AU - Emeka, Ekene Agatha
AU - Onwuegbuna, Arinze Anthony
AU - Igbodike, Emeka Philip
AU - Ajuba, Ifeoma Clara
AU - Yakasai, Ibrahim Adamu
AU - Ezechi, Oliver Chukwujekwu
AU - Ikechebelu, Joseph Ifeanyichukwu
N1 - Publisher Copyright:
© The Author(s), 2021.
PY - 2021
Y1 - 2021
N2 - Objective: To determine the hepatitis B vaccination coverage, full-dose (⩾3) coverage and the associated factors affecting uptake among pregnant women. Methods: This was a cross-sectional study among pregnant women attending antenatal care in six tertiary hospitals across all the geopolitical zones of Nigeria. Pregnant women who consented to the study completed screening questions about their hepatitis B vaccination status and coverage. The main outcome measures were hepatitis B vaccination coverage rate, dose, and factors affecting uptake. Bivariate analysis was performed by the chi-square test and conditional logistic regression analysis was used to determine variables associated with uptake of the vaccination. Odds ratios (ORs) and adjusted odds ratios (aORs) were calculated and statistical significance was accepted when p-value was < 0.05. Results: Of 159 pregnant women who completed the interview questions, 21 [13.2%, 95% confidence interval (CI) 7.9–18.5%] were vaccinated for hepatitis B for one to three doses. The numbers of doses received were: three doses (8/159, 5.0%), two doses (5/159, 3.1%), and one dose (8/159, 5.0%). The reasons for non-uptake of vaccination included: lack of awareness of the vaccine 83/138 (60.1%), inadequate access to vaccine 11/138 (8.0%), and positivity to hepatitis B virus 10/138 (7.2%). The uptake of hepatitis B vaccination was significantly affected by the level of education (OR 0.284, 95% CI 0.08–1.01, p = 0.041), but in multivariable logistic regression, adjusted for confounders, the association between hepatitis B vaccination and participants’ level of education (aOR 3.09; 95% CI 0.95–10.16; p = 0.061) did not remain significant. Conclusions: In Nigeria, the national hepatitis B vaccination coverage among pregnant women appears poor, with the full-dose coverage even poorer. The level of education was not positively associated with uptake of hepatitis B vaccination, while lack of awareness of the vaccine was the commonest reason for non-uptake. Funding: TETFund National Research Fund 2019 (grant number TETFund/DR&D/CE/NRF/STI/33).
AB - Objective: To determine the hepatitis B vaccination coverage, full-dose (⩾3) coverage and the associated factors affecting uptake among pregnant women. Methods: This was a cross-sectional study among pregnant women attending antenatal care in six tertiary hospitals across all the geopolitical zones of Nigeria. Pregnant women who consented to the study completed screening questions about their hepatitis B vaccination status and coverage. The main outcome measures were hepatitis B vaccination coverage rate, dose, and factors affecting uptake. Bivariate analysis was performed by the chi-square test and conditional logistic regression analysis was used to determine variables associated with uptake of the vaccination. Odds ratios (ORs) and adjusted odds ratios (aORs) were calculated and statistical significance was accepted when p-value was < 0.05. Results: Of 159 pregnant women who completed the interview questions, 21 [13.2%, 95% confidence interval (CI) 7.9–18.5%] were vaccinated for hepatitis B for one to three doses. The numbers of doses received were: three doses (8/159, 5.0%), two doses (5/159, 3.1%), and one dose (8/159, 5.0%). The reasons for non-uptake of vaccination included: lack of awareness of the vaccine 83/138 (60.1%), inadequate access to vaccine 11/138 (8.0%), and positivity to hepatitis B virus 10/138 (7.2%). The uptake of hepatitis B vaccination was significantly affected by the level of education (OR 0.284, 95% CI 0.08–1.01, p = 0.041), but in multivariable logistic regression, adjusted for confounders, the association between hepatitis B vaccination and participants’ level of education (aOR 3.09; 95% CI 0.95–10.16; p = 0.061) did not remain significant. Conclusions: In Nigeria, the national hepatitis B vaccination coverage among pregnant women appears poor, with the full-dose coverage even poorer. The level of education was not positively associated with uptake of hepatitis B vaccination, while lack of awareness of the vaccine was the commonest reason for non-uptake. Funding: TETFund National Research Fund 2019 (grant number TETFund/DR&D/CE/NRF/STI/33).
KW - antenatal care
KW - coverage
KW - hepatitis B
KW - pregnancy
KW - vaccination
KW - virus
UR - http://www.scopus.com/inward/record.url?scp=85118420198&partnerID=8YFLogxK
U2 - 10.1177/25151355211032595
DO - 10.1177/25151355211032595
M3 - Article
AN - SCOPUS:85118420198
SN - 2515-1355
VL - 9
JO - Therapeutic Advances in Vaccines and Immunotherapy
JF - Therapeutic Advances in Vaccines and Immunotherapy
ER -