Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke

Tapan Bhavsar, Xing Jian Liu, Hardik Patel, Ralph Stephani, Jerome O. Cantor

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

This study examined the role of endothelin-1 (ET-1) in recruiting inflammatory cells to the lung after induction of injury with either lipopolysaccharide (LPS) or cigarette smoke. Hamsters injected with either ET-1 or its precursor peptide (Big ET-1) prior to treatment with LPS or cigarette smoke had markedly increased concentrations of neutrophils in bronchoalveolar lavage fluid (BALF) despite a reduction in total numbers of BALF leukocytes. Furthermore, the effect of ET-1 on smoke-exposed animals was reversed by addition of an endothelin-A receptor antagonist. These results are consistent with preferential recruitment of neutrophils by ET-1, and suggest that inhibition of this proinflammatory mediator may decrease acute pulmonary inflammation associated with cigarette smoke and other pulmonary toxins.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalInternational Journal of COPD
Volume3
Issue number3
StatePublished - 2008
Externally publishedYes

Keywords

  • Cigarette smoke
  • Endothelin
  • Lipopolysaccahride
  • Lung
  • Neutrophis

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