PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

Alison M. Goate; Michael J. Owen; Louise A. James; Michael J. Mullan; Martin N. Rossor; Andrew R. Haynes; Martin Farrall; Lawrence Y.C. Lai; Penelope Roques; Robert Williamson; John A. Hardy

doi:10.1016/S0140-6736(89)91725-X

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

Alison M. Goate, Michael J. Owen, Louise A. James, Michael J. Mullan, Martin N. Rossor, Andrew R. Haynes, Martin Farrall, Lawrence Y.C. Lai, Penelope Roques, Robert Williamson, John A. Hardy

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Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimers disease of genetic aetiology have a predisposing locus on chromosome 21.

Original language	English
Pages (from-to)	352-355
Number of pages	4
Journal	The Lancet
Volume	333
Issue number	8634
DOIs	https://doi.org/10.1016/S0140-6736(89)91725-X
State	Published - 18 Feb 1989
Externally published	Yes

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title = "PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21",

abstract = "Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimers disease of genetic aetiology have a predisposing locus on chromosome 21.",

author = "Goate, {Alison M.} and Owen, {Michael J.} and James, {Louise A.} and Mullan, {Michael J.} and Rossor, {Martin N.} and Haynes, {Andrew R.} and Martin Farrall and Lai, {Lawrence Y.C.} and Penelope Roques and Robert Williamson and Hardy, {John A.}",

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doi = "10.1016/S0140-6736(89)91725-X",

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pages = "352--355",

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T1 - PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

AU - Goate, Alison M.

AU - Owen, Michael J.

AU - James, Louise A.

AU - Mullan, Michael J.

AU - Rossor, Martin N.

AU - Haynes, Andrew R.

AU - Farrall, Martin

AU - Lai, Lawrence Y.C.

AU - Roques, Penelope

AU - Williamson, Robert

AU - Hardy, John A.

PY - 1989/2/18

Y1 - 1989/2/18

N2 - Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimers disease of genetic aetiology have a predisposing locus on chromosome 21.

AB - Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimers disease of genetic aetiology have a predisposing locus on chromosome 21.

UR - http://www.scopus.com/inward/record.url?scp=0024559652&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(89)91725-X

DO - 10.1016/S0140-6736(89)91725-X

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AN - SCOPUS:0024559652

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VL - 333

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EP - 355

JO - The Lancet

JF - The Lancet

IS - 8634

ER -

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

Abstract

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