Predictors of outcome after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria

K. J. Halazun; G. Sapisochin; D. von Ahrens; V. G. Agopian; P. Tabrizian

doi:10.1016/j.ijsu.2020.07.029

Predictors of outcome after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria

K. J. Halazun
, G. Sapisochin
, D. von Ahrens
, V. G. Agopian
, P. Tabrizian

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The Milan criteria have been the cornerstone of selection policies for patients with hepatocellular carcinoma (HCC) awaiting liver transplantation (LT) globally for over two decades. Many groups have proposed the transplantation of patients with larger and more numerous tumors achieving comparable results. Many of these use radiologic morphometric criteria as surrogates for explant pathology to predict outcomes. Several other indices have been developed both within and beyond Milan incorporating biological indices as well as dynamic markers of response to pre-transplant locoregional treatments and waiting time. These have allowed for successful expansion of transplant selection criteria without compromising outcomes with limited organ supplies. In this review we will discuss the predictors of outcome in patients beyond Milan criteria.

Original language	English
Pages (from-to)	61-69
Number of pages	9
Journal	International Journal of Surgery
Volume	82
DOIs	https://doi.org/10.1016/j.ijsu.2020.07.029
State	Published - Oct 2020

Keywords

Downstaging
Hepatocellular carcinoma
Liver transplant
Locoregional treatment
Morphometric scores

Access to Document

10.1016/j.ijsu.2020.07.029

Cite this

@article{eceaee74f759429fb886e5cc4ecaec8c,

title = "Predictors of outcome after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria",

abstract = "The Milan criteria have been the cornerstone of selection policies for patients with hepatocellular carcinoma (HCC) awaiting liver transplantation (LT) globally for over two decades. Many groups have proposed the transplantation of patients with larger and more numerous tumors achieving comparable results. Many of these use radiologic morphometric criteria as surrogates for explant pathology to predict outcomes. Several other indices have been developed both within and beyond Milan incorporating biological indices as well as dynamic markers of response to pre-transplant locoregional treatments and waiting time. These have allowed for successful expansion of transplant selection criteria without compromising outcomes with limited organ supplies. In this review we will discuss the predictors of outcome in patients beyond Milan criteria.",

keywords = "Downstaging, Hepatocellular carcinoma, Liver transplant, Locoregional treatment, Morphometric scores",

author = "Halazun, \{K. J.\} and G. Sapisochin and \{von Ahrens\}, D. and Agopian, \{V. G.\} and P. Tabrizian",

note = "Publisher Copyright: {\textcopyright} 2020 IJS Publishing Group Ltd",

year = "2020",

month = oct,

doi = "10.1016/j.ijsu.2020.07.029",

language = "English",

volume = "82",

pages = "61--69",

journal = "International Journal of Surgery",

issn = "1743-9191",

publisher = "Wolters Kluwer Health Inc",

}

TY - JOUR

T1 - Predictors of outcome after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria

AU - Halazun, K. J.

AU - Sapisochin, G.

AU - von Ahrens, D.

AU - Agopian, V. G.

AU - Tabrizian, P.

PY - 2020/10

Y1 - 2020/10

N2 - The Milan criteria have been the cornerstone of selection policies for patients with hepatocellular carcinoma (HCC) awaiting liver transplantation (LT) globally for over two decades. Many groups have proposed the transplantation of patients with larger and more numerous tumors achieving comparable results. Many of these use radiologic morphometric criteria as surrogates for explant pathology to predict outcomes. Several other indices have been developed both within and beyond Milan incorporating biological indices as well as dynamic markers of response to pre-transplant locoregional treatments and waiting time. These have allowed for successful expansion of transplant selection criteria without compromising outcomes with limited organ supplies. In this review we will discuss the predictors of outcome in patients beyond Milan criteria.

AB - The Milan criteria have been the cornerstone of selection policies for patients with hepatocellular carcinoma (HCC) awaiting liver transplantation (LT) globally for over two decades. Many groups have proposed the transplantation of patients with larger and more numerous tumors achieving comparable results. Many of these use radiologic morphometric criteria as surrogates for explant pathology to predict outcomes. Several other indices have been developed both within and beyond Milan incorporating biological indices as well as dynamic markers of response to pre-transplant locoregional treatments and waiting time. These have allowed for successful expansion of transplant selection criteria without compromising outcomes with limited organ supplies. In this review we will discuss the predictors of outcome in patients beyond Milan criteria.

KW - Downstaging

KW - Hepatocellular carcinoma

KW - Liver transplant

KW - Locoregional treatment

KW - Morphometric scores

UR - https://www.scopus.com/pages/publications/85088803022

U2 - 10.1016/j.ijsu.2020.07.029

DO - 10.1016/j.ijsu.2020.07.029

M3 - Review article

C2 - 32707331

AN - SCOPUS:85088803022

SN - 1743-9191

VL - 82

SP - 61

EP - 69

JO - International Journal of Surgery

JF - International Journal of Surgery

ER -

Predictors of outcome after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria

Abstract

Keywords

Access to Document

Fingerprint

Cite this