Predictors of early hemorrhage in acute promyelocytic leukemia

Leonard Naymagon, Erin Moshier, Douglas Tremblay, John Mascarenhas

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Fatal hemorrhage is the most common cause of induction failure and death among patients with acute promyelocytic leukemia (APL). However, there remains no established means of hemorrhagic risk stratification in APL. In this single center retrospective study of 43 patients treated for APL group-based trajectory modeling was used to identify laboratory trends associated with major bleeding. Bleeding risk was significantly associated with particular trends in white blood cell count (WBC) and lactate dehydrogenase level (LDH). Specifically, patients who presented with high WBC and/or LDH, and whose WBC and/or LDH then proceeded to uptrend during the initial days of induction, were significantly more likely to experience major bleeding (p =.0111 and p =.0143, respectively). Additionally, there appeared to be a temporal association between WBC and LDH trends and major bleeding events. Among nonlaboratory variables, differentiation syndrome (DS) was significantly associated with major bleeding (p =.00149).

Original languageEnglish
Pages (from-to)2394-2403
Number of pages10
JournalLeukemia and Lymphoma
Volume60
Issue number10
DOIs
StatePublished - 24 Aug 2019

Keywords

  • Acute promyelocytic leukemia
  • differentiation syndrome
  • disseminated intravascular coagulation
  • hemorrhage
  • lactate dehydrogenase
  • white blood cell count

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