Predictive value of liver enzymes and alcohol consumption for risk of type 2 diabetes

Xiaokun Ma; Qingzhu Wang; Guijun Qin; Yanyan Zhao; Yinghui Zhang; Xiaojun Ma; Zhizhen Li; Zhimin Wang; Gaofei Ren; Yufang Bi; Weiqing Wang; Guang Ning

doi:10.3760/cma.j.issn.1007-3418.2015.01.013

Predictive value of liver enzymes and alcohol consumption for risk of type 2 diabetes

Xiaokun Ma
, Qingzhu Wang
, Guijun Qin
, Yanyan Zhao
, Yinghui Zhang
, Xiaojun Ma
, Zhizhen Li
, Zhimin Wang
, Gaofei Ren
, Yufang Bi
, Weiqing Wang
, Guang Ning

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

OBJECTIVE: To compare the predictive value of liver enzymes and alcohol consumption for determining risk of type 2 diabetes (T2DM).

METHODS: A cross-sectional study was conducted in Zhengzhou with a total of 2, 693 men.Participants' height, weight, and histories of smoking and drinking were recorded. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and blood glucose, as well as related metabolic indexes were detected.

RESULTS: Moderate daily alcohol consumption (more than 35 g ethanol/week and less than 140 g ethanol/week) decreased the risk of type 2 diabetes (OR =0.376, 95% CI:0.306 -0.463, P less than 0.05) but increased risk for higher levels of GGT and ALT (OR GGT =3.012, 95% CI:2.357-3.849, Pless than 0.01; ORALT =1.473, 95% CI:1.043-2.081, Pless than 0.05). In joint analyses of alcohol consumption and liver enzymes, the group of nondrinkers/light drinkers (less than or equal to 35 g ethanol/week) in the fourth quartile of GGT levels had the highest risk for type 2 diabetes (OR =12.219, 95% CI:6.217-24.016, P less than 0.01). The relationship of ALT and daily alcohol consumption with the risk of type 2 diabetes was almost the same as that of GGT (nondrinkers/light drinkers in the fourth quartile of ALT levels (OR =5.357, 95% CI:3.070-9.350, P less than 0.0 1).

CONCLUSION: GGT, ALT and daily alcohol consumption were independently associated with risk of type 2 diabetes. Nondrinkers/light drinkers with the highest levels ofGGT orALT were at high risk of type 2 diabetes.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Volume	23
Issue number	1
DOIs	https://doi.org/10.3760/cma.j.issn.1007-3418.2015.01.013
State	Published - 1 Jan 2015
Externally published	Yes

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@article{3ce02cf29d764252b6c143caa5af37cc,

title = "Predictive value of liver enzymes and alcohol consumption for risk of type 2 diabetes",

abstract = "OBJECTIVE: To compare the predictive value of liver enzymes and alcohol consumption for determining risk of type 2 diabetes (T2DM).METHODS: A cross-sectional study was conducted in Zhengzhou with a total of 2, 693 men.Participants' height, weight, and histories of smoking and drinking were recorded. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and blood glucose, as well as related metabolic indexes were detected.RESULTS: Moderate daily alcohol consumption (more than 35 g ethanol/week and less than 140 g ethanol/week) decreased the risk of type 2 diabetes (OR =0.376, 95\% CI:0.306 -0.463, P less than 0.05) but increased risk for higher levels of GGT and ALT (OR GGT =3.012, 95\% CI:2.357-3.849, Pless than 0.01; ORALT =1.473, 95\% CI:1.043-2.081, Pless than 0.05). In joint analyses of alcohol consumption and liver enzymes, the group of nondrinkers/light drinkers (less than or equal to 35 g ethanol/week) in the fourth quartile of GGT levels had the highest risk for type 2 diabetes (OR =12.219, 95\% CI:6.217-24.016, P less than 0.01). The relationship of ALT and daily alcohol consumption with the risk of type 2 diabetes was almost the same as that of GGT (nondrinkers/light drinkers in the fourth quartile of ALT levels (OR =5.357, 95\% CI:3.070-9.350, P less than 0.0 1).CONCLUSION: GGT, ALT and daily alcohol consumption were independently associated with risk of type 2 diabetes. Nondrinkers/light drinkers with the highest levels ofGGT orALT were at high risk of type 2 diabetes.",

author = "Xiaokun Ma and Qingzhu Wang and Guijun Qin and Yanyan Zhao and Yinghui Zhang and Xiaojun Ma and Zhizhen Li and Zhimin Wang and Gaofei Ren and Yufang Bi and Weiqing Wang and Guang Ning",

year = "2015",

month = jan,

day = "1",

doi = "10.3760/cma.j.issn.1007-3418.2015.01.013",

language = "English",

volume = "23",

pages = "55--58",

journal = "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",

issn = "1007-3418",

publisher = "Chinese Medical Journals Publishing House Co.Ltd",

number = "1",

}

TY - JOUR

T1 - Predictive value of liver enzymes and alcohol consumption for risk of type 2 diabetes

AU - Ma, Xiaokun

AU - Wang, Qingzhu

AU - Qin, Guijun

AU - Zhao, Yanyan

AU - Zhang, Yinghui

AU - Ma, Xiaojun

AU - Li, Zhizhen

AU - Wang, Zhimin

AU - Ren, Gaofei

AU - Bi, Yufang

AU - Wang, Weiqing

AU - Ning, Guang

PY - 2015/1/1

Y1 - 2015/1/1

N2 - OBJECTIVE: To compare the predictive value of liver enzymes and alcohol consumption for determining risk of type 2 diabetes (T2DM).METHODS: A cross-sectional study was conducted in Zhengzhou with a total of 2, 693 men.Participants' height, weight, and histories of smoking and drinking were recorded. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and blood glucose, as well as related metabolic indexes were detected.RESULTS: Moderate daily alcohol consumption (more than 35 g ethanol/week and less than 140 g ethanol/week) decreased the risk of type 2 diabetes (OR =0.376, 95% CI:0.306 -0.463, P less than 0.05) but increased risk for higher levels of GGT and ALT (OR GGT =3.012, 95% CI:2.357-3.849, Pless than 0.01; ORALT =1.473, 95% CI:1.043-2.081, Pless than 0.05). In joint analyses of alcohol consumption and liver enzymes, the group of nondrinkers/light drinkers (less than or equal to 35 g ethanol/week) in the fourth quartile of GGT levels had the highest risk for type 2 diabetes (OR =12.219, 95% CI:6.217-24.016, P less than 0.01). The relationship of ALT and daily alcohol consumption with the risk of type 2 diabetes was almost the same as that of GGT (nondrinkers/light drinkers in the fourth quartile of ALT levels (OR =5.357, 95% CI:3.070-9.350, P less than 0.0 1).CONCLUSION: GGT, ALT and daily alcohol consumption were independently associated with risk of type 2 diabetes. Nondrinkers/light drinkers with the highest levels ofGGT orALT were at high risk of type 2 diabetes.

AB - OBJECTIVE: To compare the predictive value of liver enzymes and alcohol consumption for determining risk of type 2 diabetes (T2DM).METHODS: A cross-sectional study was conducted in Zhengzhou with a total of 2, 693 men.Participants' height, weight, and histories of smoking and drinking were recorded. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and blood glucose, as well as related metabolic indexes were detected.RESULTS: Moderate daily alcohol consumption (more than 35 g ethanol/week and less than 140 g ethanol/week) decreased the risk of type 2 diabetes (OR =0.376, 95% CI:0.306 -0.463, P less than 0.05) but increased risk for higher levels of GGT and ALT (OR GGT =3.012, 95% CI:2.357-3.849, Pless than 0.01; ORALT =1.473, 95% CI:1.043-2.081, Pless than 0.05). In joint analyses of alcohol consumption and liver enzymes, the group of nondrinkers/light drinkers (less than or equal to 35 g ethanol/week) in the fourth quartile of GGT levels had the highest risk for type 2 diabetes (OR =12.219, 95% CI:6.217-24.016, P less than 0.01). The relationship of ALT and daily alcohol consumption with the risk of type 2 diabetes was almost the same as that of GGT (nondrinkers/light drinkers in the fourth quartile of ALT levels (OR =5.357, 95% CI:3.070-9.350, P less than 0.0 1).CONCLUSION: GGT, ALT and daily alcohol consumption were independently associated with risk of type 2 diabetes. Nondrinkers/light drinkers with the highest levels ofGGT orALT were at high risk of type 2 diabetes.

UR - https://www.scopus.com/pages/publications/84944677257

U2 - 10.3760/cma.j.issn.1007-3418.2015.01.013

DO - 10.3760/cma.j.issn.1007-3418.2015.01.013

M3 - Article

C2 - 25751388

AN - SCOPUS:84944677257

SN - 1007-3418

VL - 23

SP - 55

EP - 58

JO - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

JF - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

IS - 1

ER -

Predictive value of liver enzymes and alcohol consumption for risk of type 2 diabetes

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