Predictive value of C-reactive protein and left ventricular diastolic filling pattern after a non-ST elevation myocardial infarction

Achilles Zacharoulis, Vasiliki Kotseroglou, Stamatios Lerakis, Apostolos Karavidas, Sophia Arapi, Apostolos Zacharoulis

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Recent studies have shown that the odds ratio for high-sensitivity C-reactive protein (CRP) in predicting a coronary events in healthy subjects is 1.4, a value substantially less than previously reported. It is unclear whether this extends to acute coronary syndrome patients or if CRP would predict long-term events in this population. We evaluated the predictive value of CRP in patients with non-ST segment elevation myocardial infarction (NSTEMI) as their first manifestation of coronary artery disease and compared it with that of left ventricle diastolic function. Methods: Serum CRP concentration measurement and left ventricle diastolic function evaluation were performed in 51 consecutive patients with NSTEMI 48 hours, 3 months, and 6 months after infarction. Patients were followed for 1 year and events comprising the endpoints of death, new myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting were reported. Results: Thirty of 51 patients developed the endpoints. Mean CRP concentration in patients who developed any endpoint and those who did not was similar at 48 hours, 3 months, and 6 months. A strong correlation between the presence of impaired relaxation 6 months after the infarction and development of the combined endpoints was noted (P < 0.001). Conclusion: CRP has limited value in predicting future cardiovascular events in subjects with NSTEMI. Other biomarkers or a combination of other biomarkers may be needed to identify patients at high risk. Evaluation of diastolic left ventricular function not during the acute phase but 6 months later could predict adverse outcome in our series.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume331
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Keywords

  • C-reactive protein
  • Left ventricle diastolic function
  • Non-ST elevation myocardial infarction
  • Prognosis

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