TY - JOUR
T1 - Predictive utility of autistic traits in youth with ADHD
T2 - a controlled 10-year longitudinal follow-up study
AU - Joshi, Gagan
AU - DiSalvo, Maura
AU - Faraone, Stephen V.
AU - Wozniak, Janet
AU - Fried, Ronna
AU - Galdo, Maribel
AU - Belser, Abigail
AU - Hoskova, Barbora
AU - Dallenbach, Nina T.
AU - De Leon, Melissa F.
AU - Biederman, Joseph
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - The objective of this study was to investigate the stability and predictive utility of autistic traits (ATs) in youth with attention-deficit/hyperactivity disorder (ADHD). Participants were referred youth with and without ADHD, without a diagnosis of autism spectrum disorder, and their siblings, derived from identically designed longitudinal case–control family studies of boys and girls with ADHD. Subjects were assessed with structured diagnostic interviews and measures of social, cognitive, and educational functioning. The presence of ATs at baseline was operationalized using a unique profile of the Child Behavior Checklist (CBCL) consisting of an aggregate T score of ≥ 195 on the Withdrawn, Social, and Thought Problems subscales (CBCL-AT profile). At the follow-up, 83% of the ADHD youth with a positive AT profile at baseline continued to have a positive CBCL-AT profile. The presence of a positive CBCL-AT profile at baseline in youth with ADHD heralded a more compromised course characterized by a greater burden of psychopathology that emerged at an earlier age, along with poorer interpersonal, educational, and neurocognitive outcomes. Findings indicate a high level of persisting ATs in ADHD youth over time, as indexed through the CBCL-AT profile, and the presence of this profile prognosticates a compromised course in adult life in multiple domains of functioning.
AB - The objective of this study was to investigate the stability and predictive utility of autistic traits (ATs) in youth with attention-deficit/hyperactivity disorder (ADHD). Participants were referred youth with and without ADHD, without a diagnosis of autism spectrum disorder, and their siblings, derived from identically designed longitudinal case–control family studies of boys and girls with ADHD. Subjects were assessed with structured diagnostic interviews and measures of social, cognitive, and educational functioning. The presence of ATs at baseline was operationalized using a unique profile of the Child Behavior Checklist (CBCL) consisting of an aggregate T score of ≥ 195 on the Withdrawn, Social, and Thought Problems subscales (CBCL-AT profile). At the follow-up, 83% of the ADHD youth with a positive AT profile at baseline continued to have a positive CBCL-AT profile. The presence of a positive CBCL-AT profile at baseline in youth with ADHD heralded a more compromised course characterized by a greater burden of psychopathology that emerged at an earlier age, along with poorer interpersonal, educational, and neurocognitive outcomes. Findings indicate a high level of persisting ATs in ADHD youth over time, as indexed through the CBCL-AT profile, and the presence of this profile prognosticates a compromised course in adult life in multiple domains of functioning.
KW - Attention-deficit/hyperactivity disorder (ADHD)
KW - Autistic traits
KW - Longitudinal study
KW - Youth
UR - http://www.scopus.com/inward/record.url?scp=85072038319&partnerID=8YFLogxK
U2 - 10.1007/s00787-019-01384-8
DO - 10.1007/s00787-019-01384-8
M3 - Article
C2 - 31468149
AN - SCOPUS:85072038319
SN - 1018-8827
VL - 29
SP - 791
EP - 801
JO - European Child and Adolescent Psychiatry
JF - European Child and Adolescent Psychiatry
IS - 6
ER -