TY - JOUR
T1 - Prediabetes and diabetes among HIV-infected adults in Cameroon
AU - Rhee, John Y.
AU - Bahtila, Tumi Divine
AU - Palmer, Dennis
AU - Tih, Pius Muffih
AU - Aberg, Judith A.
AU - LeRoith, Derek
AU - Jao, Jennifer
N1 - Funding Information:
We would like to acknowledge the hard work of the staff at the Family Care and Treatment Center at Mbingo Baptist Hospital and thank them for helping us execute this project.
Publisher Copyright:
Copyright © 2016 John Wiley & Sons, Ltd.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background: Human immunodeficiency virus (HIV) and certain antiretrovirals are associated with diabetes. Few studies have examined the prevalence of and factors associated with diabetes among HIV-infected individuals on combination antiretroviral therapy (cART) in sub-Saharan Africa; some report prevalence estimates between 3.5–26.5% for diabetes in Cameroon and 20.2–43.5% for prediabetes in sub-Saharan Africa. Methods: In a cross-sectional study, HIV-infected individuals (16–65 years old) were screened for diabetes using haemoglobin A1c (HbA1c). We further categorized HbA1C as normoglycemia (HbA1c < 5.7%), prediabetes (HbA1c 5.7–6.4%) or diabetes (HbA1c ≥ 6.5%). Dysglycemia was defined as HbA1c ≥ 5.7%. Logistic regression modelling was used to assess factors associated with having dysglycemia. Results: Of 500 participants, 363 (72.6%) were female. Median age was 42.5 years [interquartile range (IQR): 36.5–49.5]. Nineteen patients (3.8%) had diabetes and 170 patients (34%) were classified as having prediabetes. One hundred nine (22%) had a CD4+ count <200 cells/mm3, and 464 (93%) had received >28 days of ART at time of screening. Median abdominal circumference for women was 79.5 cm (IQR: 75.5–85.3) and for men, 86.5 cm (IQR: 81.7–90.5). Adjusting for age, sex, socio-economic status, CD4 cell count, being on cART >28 days, body mass index, hypertension, history of hypertension, abdominal circumference and duration of HIV infection, larger abdominal circumference was associated with higher prevalence of prediabetes or diabetes (adjusted odds ratio = 1.07, 95% confidence interval: 1.03–1.11), while being on cART (adjusted odds ratio = 0.46, confidence interval: 0.22–0.99) was associated with lower prevalence. Conclusions: There was a high prevalence of dysglycemia among Cameroonian HIV-infected adults. Larger abdominal circumference was associated with higher prevalence, while cART was associated with lower prevalence.
AB - Background: Human immunodeficiency virus (HIV) and certain antiretrovirals are associated with diabetes. Few studies have examined the prevalence of and factors associated with diabetes among HIV-infected individuals on combination antiretroviral therapy (cART) in sub-Saharan Africa; some report prevalence estimates between 3.5–26.5% for diabetes in Cameroon and 20.2–43.5% for prediabetes in sub-Saharan Africa. Methods: In a cross-sectional study, HIV-infected individuals (16–65 years old) were screened for diabetes using haemoglobin A1c (HbA1c). We further categorized HbA1C as normoglycemia (HbA1c < 5.7%), prediabetes (HbA1c 5.7–6.4%) or diabetes (HbA1c ≥ 6.5%). Dysglycemia was defined as HbA1c ≥ 5.7%. Logistic regression modelling was used to assess factors associated with having dysglycemia. Results: Of 500 participants, 363 (72.6%) were female. Median age was 42.5 years [interquartile range (IQR): 36.5–49.5]. Nineteen patients (3.8%) had diabetes and 170 patients (34%) were classified as having prediabetes. One hundred nine (22%) had a CD4+ count <200 cells/mm3, and 464 (93%) had received >28 days of ART at time of screening. Median abdominal circumference for women was 79.5 cm (IQR: 75.5–85.3) and for men, 86.5 cm (IQR: 81.7–90.5). Adjusting for age, sex, socio-economic status, CD4 cell count, being on cART >28 days, body mass index, hypertension, history of hypertension, abdominal circumference and duration of HIV infection, larger abdominal circumference was associated with higher prevalence of prediabetes or diabetes (adjusted odds ratio = 1.07, 95% confidence interval: 1.03–1.11), while being on cART (adjusted odds ratio = 0.46, confidence interval: 0.22–0.99) was associated with lower prevalence. Conclusions: There was a high prevalence of dysglycemia among Cameroonian HIV-infected adults. Larger abdominal circumference was associated with higher prevalence, while cART was associated with lower prevalence.
KW - Cameroon
KW - HIV
KW - antiretroviral therapy
KW - diabetes
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=84985982504&partnerID=8YFLogxK
U2 - 10.1002/dmrr.2792
DO - 10.1002/dmrr.2792
M3 - Article
C2 - 26891253
AN - SCOPUS:84985982504
SN - 1520-7552
VL - 32
SP - 544
EP - 549
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
IS - 6
ER -