Precursor stage of hepatocellular neoplasm following long exposure to orally administered contraceptives

Swan N. Thung, Michael A. Gerber

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Hepatic neoplasms and peliosis are known to occur in women taking contraceptives orally. We observed hyperplasia of hepatocytes combined with hypertrophy of sinusoidal lining cells and sinusoidal dilatation with progression to peliosis in the liver of a patient who had been taking such contraceptives for 10 years. These changes resembled the precursor stage in the development of hepatic angiosarcoma induced by vinyl chloride, Thorotrast, and arsenic. In users of orally administered contraceptives these findings may precede the development of hepatocellular neoplasms.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalHuman Pathology
Volume12
Issue number5
DOIs
StatePublished - May 1981

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