Preclinical models of antipsychotic drug action

José L. Moreno, Javier González-Maeso

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Abstract One of the main obstacles faced by translational neuroscience is the development of animal models of psychiatric disorders. Behavioural pharmacology studies indicate that psychedelic drugs, such as lysergic acid diethylamide (LSD) and dissociative drugs, such as phencyclidine (PCP), induce in healthy human volunteers psychotic and cognitive symptoms that resemble some of those observed in schizophrenia patients. Serotonin 5-HT2A and metabotropic glutamate 2 receptors have been involved in the mechanism of action of psychedelic and dissociative drugs. Here we review recent advances using LSD-like and PCP-like drugs in rodent models that implicate these receptors in the neurobiology of schizophrenia and its treatment.

Original languageEnglish
Pages (from-to)2131-2144
Number of pages14
JournalInternational Journal of Neuropsychopharmacology
Volume16
Issue number10
DOIs
StatePublished - Nov 2013

Keywords

  • Antipsychotic drugs
  • epigenetics
  • lysergic acid diethylamide
  • metabotropic glutamate 2 receptor
  • mouse models
  • phencyclidine
  • schizophrenia
  • serotonin 5-HT2A receptor

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