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Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment

  • Nikolaos Vitorakis
  • , Antonios N. Gargalionis
  • , Kostas A. Papavassiliou
  • , Christos Adamopoulos
  • , Athanasios G. Papavassiliou

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Pancreatic cancer demonstrates an ever-increasing incidence over the last years and represents one of the top causes of cancer-associated mortality. Cells of the tumor microenvironment (TME) interact with cancer cells in pancreatic ductal adenocarcinoma (PDAC) tumors to preserve cancer cells’ metabolism, inhibit drug delivery, enhance immune suppression mechanisms and finally develop resistance to chemotherapy and immunotherapy. New strategies target TME genetic alterations and specific pathways in cell populations of the TME. Complex molecular interactions develop between PDAC cells and TME cell populations including cancer-associated fibroblasts, myeloid-derived suppressor cells, pancreatic stellate cells, tumor-associated macrophages, tumor-associated neutrophils, and regulatory T cells. In the present review, we aim to fully explore the molecular landscape of the pancreatic cancer TME cell populations and discuss current TME targeting strategies to provide thoughts for further research and preclinical testing.

Original languageEnglish
Article number2876
JournalCancers
Volume16
Issue number16
DOIs
StatePublished - Aug 2024

Keywords

  • cancer-associated fibroblasts (CAFs)
  • immunotherapy
  • myeloid-derived suppressor cells (MDSCs)
  • pancreatic cancer
  • pancreatic ductal adenocarcinoma (PDAC)
  • tumor microenvironment (TME)
  • tumor-associated macrophages (TAMs)

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