TY - JOUR
T1 - Pre-existing Hemagglutinin Stalk Antibodies Correlate with Protection of Lower Respiratory Symptoms in Flu-Infected Transplant Patients
AU - Aydillo, Teresa
AU - Escalera, Alba
AU - Strohmeier, Shirin
AU - Aslam, Sadaf
AU - Sanchez-Cespedes, Javier
AU - Ayllon, Juan
AU - Roca-Oporto, Cristina
AU - Perez-Romero, Pilar
AU - Montejo, Miguel
AU - Gavalda, Joan
AU - Munoz, Patricia
AU - Lopez-Medrano, Francisco
AU - Carratala, Jordi
AU - Krammer, Florian
AU - García-Sastre, Adolfo
AU - Cordero, Elisa
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/11/17
Y1 - 2020/11/17
N2 - Hemagglutination-inhibitory antibodies are usually highly strain specific with little effect on infection with drifted or shifted strains. The significance of broadly cross-reactive non-HAI anti-influenza antibodies against conserved domains of virus glycoproteins, such as the hemagglutinin (HA) stalk, is of great interest. We characterize a cohort of 40 H1N1pmd09 influenza-infected patients and identify lower respiratory symptoms (LRSs) as a predictor for development of pneumonia. A binomial logistic regression of log10 pre-existing antibody values shows that the probability of LRS occurrence decreased with increased anti-HA full-length and stalk antibody ELISA titers. However, a multilevel logistic regression model adjusted by other potential serocorrelates demonstrates that only antibodies directed against the stalk of HA correlate with protection from lower respiratory infection, limiting disease progression. Our predictive model indicates that a threshold of protective immunity based on broadly cross-reactive HA stalk antibodies could be feasible.
AB - Hemagglutination-inhibitory antibodies are usually highly strain specific with little effect on infection with drifted or shifted strains. The significance of broadly cross-reactive non-HAI anti-influenza antibodies against conserved domains of virus glycoproteins, such as the hemagglutinin (HA) stalk, is of great interest. We characterize a cohort of 40 H1N1pmd09 influenza-infected patients and identify lower respiratory symptoms (LRSs) as a predictor for development of pneumonia. A binomial logistic regression of log10 pre-existing antibody values shows that the probability of LRS occurrence decreased with increased anti-HA full-length and stalk antibody ELISA titers. However, a multilevel logistic regression model adjusted by other potential serocorrelates demonstrates that only antibodies directed against the stalk of HA correlate with protection from lower respiratory infection, limiting disease progression. Our predictive model indicates that a threshold of protective immunity based on broadly cross-reactive HA stalk antibodies could be feasible.
KW - correlates of protection
KW - influenza antibodies
KW - transplant patients
KW - viral pneumonia
UR - http://www.scopus.com/inward/record.url?scp=85096622891&partnerID=8YFLogxK
U2 - 10.1016/j.xcrm.2020.100130
DO - 10.1016/j.xcrm.2020.100130
M3 - Article
C2 - 33294855
AN - SCOPUS:85096622891
SN - 2666-3791
VL - 1
JO - Cell Reports Medicine
JF - Cell Reports Medicine
IS - 8
M1 - 100130
ER -