Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

Thomas J. Povsic; Monica G. Lawrence; A. Michael Lincoff; Roxana Mehran; Christopher P. Rusconi; Steven L. Zelenkofske; Zhen Huang; Jeffrey Sailstad; Paul W. Armstrong; P. Gabriel Steg; Christoph Bode; Richard C. Becker; John H. Alexander; N. Franklin Adkinson; Arnold I. Levinson

doi:10.1016/j.jaci.2016.04.058

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

Thomas J. Povsic
, Monica G. Lawrence
, A. Michael Lincoff
, Roxana Mehran
, Christopher P. Rusconi
, Steven L. Zelenkofske
, Zhen Huang
, Jeffrey Sailstad
, Paul W. Armstrong
, P. Gabriel Steg
, Christoph Bode
, Richard C. Becker
, John H. Alexander
, N. Franklin Adkinson
, Arnold I. Levinson

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Original language	English
Pages (from-to)	1712-1715
Number of pages	4
Journal	Journal of Allergy and Clinical Immunology
Volume	138
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2016.04.058
State	Published - 1 Dec 2016

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10.1016/j.jaci.2016.04.058

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Povsic, T. J., Lawrence, M. G., Lincoff, A. M., Mehran, R., Rusconi, C. P., Zelenkofske, S. L., Huang, Z., Sailstad, J., Armstrong, P. W., Steg, P. G., Bode, C., Becker, R. C., Alexander, J. H., Adkinson, N. F., & Levinson, A. I. (2016). Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer. Journal of Allergy and Clinical Immunology, 138(6), 1712-1715. https://doi.org/10.1016/j.jaci.2016.04.058

@article{7738445c74e840cab1c3bc5e4bc2fef5,

title = "Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer",

author = "Povsic, \{Thomas J.\} and Lawrence, \{Monica G.\} and Lincoff, \{A. Michael\} and Roxana Mehran and Rusconi, \{Christopher P.\} and Zelenkofske, \{Steven L.\} and Zhen Huang and Jeffrey Sailstad and Armstrong, \{Paul W.\} and Steg, \{P. Gabriel\} and Christoph Bode and Becker, \{Richard C.\} and Alexander, \{John H.\} and Adkinson, \{N. Franklin\} and Levinson, \{Arnold I.\}",

note = "Funding Information: The REGULATE-PCI trial and this analysis were funded by Regado Biosciences Inc . The sponsor of the trial, Regado Biosciences, participated in the design of the trial and the analysis plan for biospecimens collected in the trial, in collaboration with the investigators of the trial. The sponsor selected the core laboratories for the analysis, but did not perform the analyses or analyze the data. The corresponding author drafted this manuscript and made all revisions on the basis of input from the coauthors, including those employed by the sponsor. The sponsor had no role in the decision to submit the manuscript for publication. ",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.jaci.2016.04.058",

language = "English",

volume = "138",

pages = "1712--1715",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "6",

}

Povsic, TJ, Lawrence, MG, Lincoff, AM, Mehran, R, Rusconi, CP, Zelenkofske, SL, Huang, Z, Sailstad, J, Armstrong, PW, Steg, PG, Bode, C, Becker, RC, Alexander, JH, Adkinson, NF & Levinson, AI 2016, 'Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer', Journal of Allergy and Clinical Immunology, vol. 138, no. 6, pp. 1712-1715. https://doi.org/10.1016/j.jaci.2016.04.058

TY - JOUR

T1 - Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

AU - Povsic, Thomas J.

AU - Lawrence, Monica G.

AU - Lincoff, A. Michael

AU - Mehran, Roxana

AU - Rusconi, Christopher P.

AU - Zelenkofske, Steven L.

AU - Huang, Zhen

AU - Sailstad, Jeffrey

AU - Armstrong, Paul W.

AU - Steg, P. Gabriel

AU - Bode, Christoph

AU - Becker, Richard C.

AU - Alexander, John H.

AU - Adkinson, N. Franklin

AU - Levinson, Arnold I.

N1 - Funding Information: The REGULATE-PCI trial and this analysis were funded by Regado Biosciences Inc . The sponsor of the trial, Regado Biosciences, participated in the design of the trial and the analysis plan for biospecimens collected in the trial, in collaboration with the investigators of the trial. The sponsor selected the core laboratories for the analysis, but did not perform the analyses or analyze the data. The corresponding author drafted this manuscript and made all revisions on the basis of input from the coauthors, including those employed by the sponsor. The sponsor had no role in the decision to submit the manuscript for publication.

PY - 2016/12/1

Y1 - 2016/12/1

UR - https://www.scopus.com/pages/publications/84994276041

U2 - 10.1016/j.jaci.2016.04.058

DO - 10.1016/j.jaci.2016.04.058

M3 - Article

C2 - 27522158

AN - SCOPUS:84994276041

SN - 0091-6749

VL - 138

SP - 1712

EP - 1715

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 6

ER -