Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: Results from the PROSPER MRI study

Frieke M.A. Box; Jeroen Van Der Grond; Anton J.M. De Craen; Inge H. Palm-Meinders; Rob J. Van Der Geest; J. Wouter Jukema; Johan H.C. Reiber; Mark A. Van Buchem; Gerard J. Blauw

doi:10.1161/01.STR.0000260206.56774.aa

Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: Results from the PROSPER MRI study

Frieke M.A. Box, Jeroen Van Der Grond, Anton J.M. De Craen, Inge H. Palm-Meinders, Rob J. Van Der Geest, J. Wouter Jukema, Johan H.C. Reiber, Mark A. Van Buchem, Gerard J. Blauw

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. METHODS - In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. RESULTS - WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased faster in the pravastatin group (P<0.04, P<0.02). Blood volume flow did not differ between the groups. CONCLUSIONS - In elderly subjects, the WSS and blood velocity of the internal carotid artery declines significantly over time and this decline is more pronounced in subjects treated with 40 mg pravastatin compared with the placebo group.

Original language	English
Pages (from-to)	1374-1376
Number of pages	3
Journal	Stroke
Volume	38
Issue number	4
DOIs	https://doi.org/10.1161/01.STR.0000260206.56774.aa
State	Published - Apr 2007
Externally published	Yes

Keywords

Blood flow
Blood flow velocity
Computer-assisted
Image processing
Magnetic resonance imaging
Statins

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Box, F. M. A., Van Der Grond, J., De Craen, A. J. M., Palm-Meinders, I. H., Van Der Geest, R. J., Jukema, J. W., Reiber, J. H. C., Van Buchem, M. A., & Blauw, G. J. (2007). Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: Results from the PROSPER MRI study. Stroke, 38(4), 1374-1376. https://doi.org/10.1161/01.STR.0000260206.56774.aa

@article{593ba90bfa594acc8ab493f84d4f5e42,

title = "Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: Results from the PROSPER MRI study",

abstract = "BACKGROUND AND PURPOSE - Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. METHODS - In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. RESULTS - WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased faster in the pravastatin group (P<0.04, P<0.02). Blood volume flow did not differ between the groups. CONCLUSIONS - In elderly subjects, the WSS and blood velocity of the internal carotid artery declines significantly over time and this decline is more pronounced in subjects treated with 40 mg pravastatin compared with the placebo group.",

keywords = "Blood flow, Blood flow velocity, Computer-assisted, Image processing, Magnetic resonance imaging, Statins",

author = "Box, {Frieke M.A.} and {Van Der Grond}, Jeroen and {De Craen}, {Anton J.M.} and Palm-Meinders, {Inge H.} and {Van Der Geest}, {Rob J.} and Jukema, {J. Wouter} and Reiber, {Johan H.C.} and {Van Buchem}, {Mark A.} and Blauw, {Gerard J.}",

year = "2007",

month = apr,

doi = "10.1161/01.STR.0000260206.56774.aa",

language = "English",

volume = "38",

pages = "1374--1376",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "4",

}

Box, FMA, Van Der Grond, J, De Craen, AJM, Palm-Meinders, IH, Van Der Geest, RJ, Jukema, JW, Reiber, JHC, Van Buchem, MA & Blauw, GJ 2007, 'Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: Results from the PROSPER MRI study', Stroke, vol. 38, no. 4, pp. 1374-1376. https://doi.org/10.1161/01.STR.0000260206.56774.aa

TY - JOUR

T1 - Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume

T2 - Results from the PROSPER MRI study

AU - Box, Frieke M.A.

AU - Van Der Grond, Jeroen

AU - De Craen, Anton J.M.

AU - Palm-Meinders, Inge H.

AU - Van Der Geest, Rob J.

AU - Jukema, J. Wouter

AU - Reiber, Johan H.C.

AU - Van Buchem, Mark A.

AU - Blauw, Gerard J.

PY - 2007/4

Y1 - 2007/4

N2 - BACKGROUND AND PURPOSE - Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. METHODS - In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. RESULTS - WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased faster in the pravastatin group (P<0.04, P<0.02). Blood volume flow did not differ between the groups. CONCLUSIONS - In elderly subjects, the WSS and blood velocity of the internal carotid artery declines significantly over time and this decline is more pronounced in subjects treated with 40 mg pravastatin compared with the placebo group.

AB - BACKGROUND AND PURPOSE - Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. METHODS - In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. RESULTS - WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased faster in the pravastatin group (P<0.04, P<0.02). Blood volume flow did not differ between the groups. CONCLUSIONS - In elderly subjects, the WSS and blood velocity of the internal carotid artery declines significantly over time and this decline is more pronounced in subjects treated with 40 mg pravastatin compared with the placebo group.

KW - Blood flow

KW - Blood flow velocity

KW - Computer-assisted

KW - Image processing

KW - Magnetic resonance imaging

KW - Statins

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U2 - 10.1161/01.STR.0000260206.56774.aa

DO - 10.1161/01.STR.0000260206.56774.aa

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AN - SCOPUS:34247857675

SN - 0039-2499

VL - 38

SP - 1374

EP - 1376

JO - Stroke

JF - Stroke

IS - 4

ER -

Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: Results from the PROSPER MRI study

Abstract

Keywords

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