Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain stimulation for treatment-resistant depression

Patricio Riva-Posse, Paul E. Holtzheimer, Steven J. Garlow, Helen S. Mayberg

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Background: Deep brain stimulation has been investigated in the past decade as a viable intervention for treatment-resistant depression. Methods: Several anatomic targets have been tested, with the most extensive published experience found for the subcallosal cingulate (SCC) white matter. Results: This article reviews the current state of clinical research of SCC deep brain stimulation for treatment-resistant depression, including an overview of the rationale for targeting SCC, practical considerations for subject recruitment and evaluation, surgical planning, and stimulation parameters. Conclusion: Clinical management of patients in the initial and long-term naturalistic phases of treatment, including the potential role for psychotherapeutic rehabilitation, is discussed.

Original languageEnglish
Pages (from-to)S27.e25-S27.e34
JournalWorld Neurosurgery
Volume80
Issue number3-4
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Deep brain stimulation
  • Subcallosal cingulated
  • Treatment-resistant depression

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