Practical concerns and controversies in the management of alcoholic hepatitis

Gene Y. Im, Michael R. Lucey

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Recent advances in the treatment of alcoholic hepatitis (AH) have reinforced the utility of glucocorticoids, a treatment that has been in use for nearly 4 decades, to enhance short-term survival. As multi-institutional consortia research new therapeutic advances, this orphan disease, which afflicts younger patients and has poor outcomes, continues to be difficult to manage. AH has a protean clinical presentation and course, with various prediction models and treatment approaches that can challenge even experienced providers. This review addresses 4 key controversies and other practical issues associated with the diagnosis, prognosis, management, and treatment of patients with AH.

Original languageEnglish
Pages (from-to)478-489
Number of pages12
JournalGastroenterology and Hepatology
Volume12
Issue number8
StatePublished - Aug 2016

Keywords

  • Alcoholic hepatitis
  • Discriminant function
  • Early liver transplantation
  • Glasgow alcoholic hepatitis score
  • Lille model
  • Model for end-stage liver disease

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