PPAR-γ and aging: One link through klotho?

Ruihua Zhang; Feng Zheng

doi:10.1038/ki.2008.382

PPAR-γ and aging: One link through klotho?

Ruihua Zhang, Feng Zheng

Research output: Contribution to journal › Comment/debate

47 Scopus citations

Abstract

PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.

Original language	English
Pages (from-to)	702-704
Number of pages	3
Journal	Kidney International
Volume	74
Issue number	6
DOIs	https://doi.org/10.1038/ki.2008.382
State	Published - Sep 2008

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title = "PPAR-γ and aging: One link through klotho?",

abstract = "PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.",

author = "Ruihua Zhang and Feng Zheng",

note = "Funding Information: We thank Gary E. Striker for critical reading of the manuscript. This work is supported by United States National Institutes of Health grant 5R01 AG027628-03 to Feng Zheng.",

year = "2008",

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journal = "Kidney International",

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T1 - PPAR-γ and aging

T2 - One link through klotho?

AU - Zhang, Ruihua

AU - Zheng, Feng

N1 - Funding Information: We thank Gary E. Striker for critical reading of the manuscript. This work is supported by United States National Institutes of Health grant 5R01 AG027628-03 to Feng Zheng.

PY - 2008/9

Y1 - 2008/9

N2 - PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.

AB - PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.

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U2 - 10.1038/ki.2008.382

DO - 10.1038/ki.2008.382

M3 - Comment/debate

C2 - 18756295

AN - SCOPUS:50849105720

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VL - 74

SP - 702

EP - 704

JO - Kidney International

JF - Kidney International

IS - 6

ER -

PPAR-γ and aging: One link through klotho?

Abstract

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