Potentiation of vincristine cytotoxicity by hormones: Corticosteroids, androgens, estrogens and progestins

Fred Rosner, Yashar Hirshaut, Hans W. Grünwald, Stanley Deutsch

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete potentiation of vincristine cytotoxicity comparable to that achieved by the addition of prednisolone was observed when the latter drug was replaced by a variety of mineralocorticoids (aldosterone, desoxycorticosterone and fludrocortisone), glucocorticoids (hydrocortisone, dexamethasone), androgens (testosterone, methyltestosterone, androsterone, dehydroepiandrosterone, etiocholanolone), estrogens (estrone, 17‐βestradiol) and progestins (progesterone, pregnanediol). No potentiation of cytotoxicity was observed when nonsteroidal hormones (thyroxin, ACTH) were added to vincristine. It is concluded that a wide variety of compounds with the basic perhydrocyclopentano‐phenanthrene nucleus of the steroid molecule are capable of enhancing the cytotoxicity achieved with vincristine.

Original languageEnglish
Pages (from-to)305-314
Number of pages10
JournalAmerican Journal of Hematology
Volume5
Issue number4
DOIs
StatePublished - 1978
Externally publishedYes

Keywords

  • cytotoxicity
  • hormone potentiation of vincristine cytotoxicity
  • vincristine

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