Potential mechanisms promoting restenosis in diabetic patients

Research output: Contribution to journalReview articlepeer-review

311 Scopus citations

Abstract

Diabetes is associated with greater restenosis rates after successful balloon angioplasty. The metabolic alterations that occur as a result of hyperglycemia or hyperinsulinemia can accelerate many of the pathophysiologic processes that lead to restenosis. Diabetes results in endothelial dysfunction and accelerated platelet deposition, which increase the propensity to thrombosis. Several growth factors known to promote the restenosis process are overexpressed in the presence of hyperglycemia. Advanced glycosylation promotes inflammatory cell recruitment and smooth muscle cell proliferation. Many of the potential mechanisms promoting restenosis in diabetic patients can be ameliorated by improved metabolic control.

Original languageEnglish
Pages (from-to)528-535
Number of pages8
JournalJournal of the American College of Cardiology
Volume27
Issue number3
DOIs
StatePublished - 1 Mar 1996

Fingerprint

Dive into the research topics of 'Potential mechanisms promoting restenosis in diabetic patients'. Together they form a unique fingerprint.

Cite this