TY - GEN
T1 - Potential mechanism for transition between acute hypercapnia during sleep to chronic hypercapnia during wakefulness in obstructive sleep apnea
AU - Berger, Kenneth I.
AU - Norman, Robert G.
AU - Ayappa, Indu
AU - Oppenheimer, Beno W.
AU - Rapoport, David M.
AU - Goldring, Roberta M.
PY - 2008
Y1 - 2008
N2 - This paper presents a series of experiments, both in patients and computer models, investigating the transition from acute to chronic hypercapnia in OSA. The data demonstrate that acute hypercapnia during periodic breathing occurs due to either reduction in magnitude of inter-event ventilation and/or reduction in interevent ventilatory duration relative to duration of the preceding event. The transition between acute hypercapnia during sleep and chronic sustained hypercapnia during wakefulness may be determined by an interaction between respiratory control and renal handling of HCO3-
AB - This paper presents a series of experiments, both in patients and computer models, investigating the transition from acute to chronic hypercapnia in OSA. The data demonstrate that acute hypercapnia during periodic breathing occurs due to either reduction in magnitude of inter-event ventilation and/or reduction in interevent ventilatory duration relative to duration of the preceding event. The transition between acute hypercapnia during sleep and chronic sustained hypercapnia during wakefulness may be determined by an interaction between respiratory control and renal handling of HCO3-
UR - http://www.scopus.com/inward/record.url?scp=38449099345&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-73693-8_75
DO - 10.1007/978-0-387-73693-8_75
M3 - Conference contribution
C2 - 18085312
AN - SCOPUS:38449099345
SN - 9780387736921
T3 - Advances in Experimental Medicine and Biology
SP - 431
EP - 436
BT - Integration in Respiratory Control
ER -