TY - JOUR
T1 - Potent in vitro anticancer activities of ring-expanded ("fat") nucleosides containing the imidazo[4,5-E][1,3]diazepine ring system
AU - Gill, Juliana K.
AU - Wang, Lijuan
AU - Bretner, Maria
AU - Newman, Rachel
AU - Kyprianou, Natasha
AU - Hosmane, Ramachandra S.
PY - 2001
Y1 - 2001
N2 - The ring-expanded ("fat") nucleoside, 4,8-diamino-6-imino-6H-1-β-D-ribofuranosylimidazo[4,5-e][1,3]diazepine (1) and its 2′,3′,5′-tri-O-benzoyl derivative (2) exhibited potent broad spectrum anticancer activities in vitro against a wide variety of human tumor cell lines. The tribenzoyl derivative 2 was found to be considerably more active than the parent nucleoside 1. Further studies using human prostate cancer cells PC-3 and DU-145 suggest that the treatment of exponentially growing culture cells with 1 and 2 leads to marked loss of cell viability in a dose-dependent manner.
AB - The ring-expanded ("fat") nucleoside, 4,8-diamino-6-imino-6H-1-β-D-ribofuranosylimidazo[4,5-e][1,3]diazepine (1) and its 2′,3′,5′-tri-O-benzoyl derivative (2) exhibited potent broad spectrum anticancer activities in vitro against a wide variety of human tumor cell lines. The tribenzoyl derivative 2 was found to be considerably more active than the parent nucleoside 1. Further studies using human prostate cancer cells PC-3 and DU-145 suggest that the treatment of exponentially growing culture cells with 1 and 2 leads to marked loss of cell viability in a dose-dependent manner.
UR - http://www.scopus.com/inward/record.url?scp=0034850925&partnerID=8YFLogxK
U2 - 10.1081/NCN-100002487
DO - 10.1081/NCN-100002487
M3 - Article
C2 - 11562954
AN - SCOPUS:0034850925
SN - 1525-7770
VL - 20
SP - 1043
EP - 1045
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 4-7
ER -