Posttraumatic Stress Disorder: Neurobiology

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Posttraumatic stress disorder (PTSD) can be characterized as the persistence of heightened fear despite the cessation of a threatening stimulus, resulting in persistent, vivid recall of traumatic events, autonomic hyperarousal, avoidance of nontraumatic stimuli, and emotional numbing. This article explores the neural pathways involved in the fear response, the neurotransmitters that modulate this response, and the most recent evidence for the physiologic processes that are disordered both before and after the onset of PTSD.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Number of pages6
ISBN (Print)9780080450469
StatePublished - 2009
Externally publishedYes


  • Amygdala
  • Anterior cingulate gyrus
  • Corticotropin-releasing hormone (CRH)
  • Estrogen
  • Galanin
  • Hippocampus
  • Hypothalamic-pituitary axis
  • Locus coeruleus
  • Medial prefrontal cortex
  • Neuropeptide Y
  • Norepinephrine
  • Posttraumatic stress disorder (PTSD)
  • Serotonin
  • Testosterone


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