Posttraumatic Stress Disorder: Neurobiology

P. Runnels; A. S. New; D. S. Charney

doi:10.1016/B978-008045046-9.00523-4

Posttraumatic Stress Disorder: Neurobiology

P. Runnels, A. S. New, D. S. Charney

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Posttraumatic stress disorder (PTSD) can be characterized as the persistence of heightened fear despite the cessation of a threatening stimulus, resulting in persistent, vivid recall of traumatic events, autonomic hyperarousal, avoidance of nontraumatic stimuli, and emotional numbing. This article explores the neural pathways involved in the fear response, the neurotransmitters that modulate this response, and the most recent evidence for the physiologic processes that are disordered both before and after the onset of PTSD.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd.
Pages	847-852
Number of pages	6
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00523-4
State	Published - 2009
Externally published	Yes

Keywords

Amygdala
Anterior cingulate gyrus
Corticotropin-releasing hormone (CRH)
Estrogen
Galanin
Hippocampus
Hypothalamic-pituitary axis
Locus coeruleus
Medial prefrontal cortex
Neuropeptide Y
Norepinephrine
Posttraumatic stress disorder (PTSD)
Serotonin
Testosterone

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10.1016/B978-008045046-9.00523-4

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title = "Posttraumatic Stress Disorder: Neurobiology",

abstract = "Posttraumatic stress disorder (PTSD) can be characterized as the persistence of heightened fear despite the cessation of a threatening stimulus, resulting in persistent, vivid recall of traumatic events, autonomic hyperarousal, avoidance of nontraumatic stimuli, and emotional numbing. This article explores the neural pathways involved in the fear response, the neurotransmitters that modulate this response, and the most recent evidence for the physiologic processes that are disordered both before and after the onset of PTSD.",

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T1 - Posttraumatic Stress Disorder

T2 - Neurobiology

AU - Runnels, P.

AU - New, A. S.

AU - Charney, D. S.

PY - 2009

Y1 - 2009

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KW - Amygdala

KW - Anterior cingulate gyrus

KW - Corticotropin-releasing hormone (CRH)

KW - Estrogen

KW - Galanin

KW - Hippocampus

KW - Hypothalamic-pituitary axis

KW - Locus coeruleus

KW - Medial prefrontal cortex

KW - Neuropeptide Y

KW - Norepinephrine

KW - Posttraumatic stress disorder (PTSD)

KW - Serotonin

KW - Testosterone

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DO - 10.1016/B978-008045046-9.00523-4

M3 - Chapter

AN - SCOPUS:84882815891

SN - 9780080450469

SP - 847

EP - 852

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd.

ER -

Posttraumatic Stress Disorder: Neurobiology

Abstract

Keywords

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