Posttransplant lymphoproliferative disease presenting as sudden respiratory arrest in a three-year-old child

Karin Hague, Peter Catalano, James Strauchen, Michael Rothschild, Billie Fyfe

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Posttransplant lymphoproliferative disease (PTLD) is an occasional complication of pediatric organ transplantation that, heretofore, has not been associated with airway obstruction. We report the first documented case of PTLD associated with complete airway obstruction resulting in sudden respiratory arrest and death in a 3-year-old child. This is contrasted to a subsequent case of PTLD wherein heightened clinical suspicion and prompt tonsillectomy resulted in a definitive diagnosis and improved outcome. The early clinical hallmarks of PTLD are a mononucleosis-like syndrome, tonsillar enlargement, and positive Epstein-Barr virus seroconversion. The potential for a fatal outcome of PTLD involving Waldeyer's ring components warrants early recognition and aggressive treatment.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalAnnals of Otology, Rhinology and Laryngology
Volume106
Issue number3
DOIs
StatePublished - 1997

Keywords

  • posttransplant lymphoproliferative disease
  • respiratory tract

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