Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

Robert D. Blitzer; Tony Wong; Rabin Nouranifar; Ravi Iyengar; Emmanuel M. Landau

doi:10.1016/0896-6273(95)90018-7

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

Robert D. Blitzer, Tony Wong, Rabin Nouranifar, Ravi Iyengar, Emmanuel M. Landau

Research output: Contribution to journal › Article › peer-review

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Abstract

The role of the CAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated CAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca²⁺/calmodulin-mediated stimulation of postsynaptic adenylyl cyclase. The early phase of LTP produced by the same pattern of high frequency stimulation was dependent on postsynaptic cAMP. However, synaptic transmission was not increased by postsynaptic application of CAMP. Early LTP became cAMP-independent when protein phosphatase inhibitors were injected postsynaptically. These observations indicate that in early UP the cAMP signaling pathway, instead of transmitting signals for the generation of LTP, gates UP through postsynaptic protein phosphatases.

Original language	English
Pages (from-to)	1403-1414
Number of pages	12
Journal	Neuron
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/0896-6273(95)90018-7
State	Published - Dec 1995

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@article{588dcc8314444c2183544f54f4378b66,

title = "Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region",

abstract = "The role of the CAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated CAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca2+/calmodulin-mediated stimulation of postsynaptic adenylyl cyclase. The early phase of LTP produced by the same pattern of high frequency stimulation was dependent on postsynaptic cAMP. However, synaptic transmission was not increased by postsynaptic application of CAMP. Early LTP became cAMP-independent when protein phosphatase inhibitors were injected postsynaptically. These observations indicate that in early UP the cAMP signaling pathway, instead of transmitting signals for the generation of LTP, gates UP through postsynaptic protein phosphatases.",

author = "Blitzer, {Robert D.} and Tony Wong and Rabin Nouranifar and Ravi Iyengar and Landau, {Emmanuel M.}",

note = "Funding Information: This research was supported by a NARSAD Young Investigator Grant (R. D. B.), a VA Merit Grant (E. M. L.). the Mt. Sinai School of Medicine (E. M. L.), and National Institutes of Health grants CA44998 and DK36761 (R. I.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.",

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doi = "10.1016/0896-6273(95)90018-7",

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volume = "15",

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journal = "Neuron",

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T1 - Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

AU - Blitzer, Robert D.

AU - Wong, Tony

AU - Nouranifar, Rabin

AU - Iyengar, Ravi

AU - Landau, Emmanuel M.

N1 - Funding Information: This research was supported by a NARSAD Young Investigator Grant (R. D. B.), a VA Merit Grant (E. M. L.). the Mt. Sinai School of Medicine (E. M. L.), and National Institutes of Health grants CA44998 and DK36761 (R. I.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.

PY - 1995/12

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N2 - The role of the CAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated CAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca2+/calmodulin-mediated stimulation of postsynaptic adenylyl cyclase. The early phase of LTP produced by the same pattern of high frequency stimulation was dependent on postsynaptic cAMP. However, synaptic transmission was not increased by postsynaptic application of CAMP. Early LTP became cAMP-independent when protein phosphatase inhibitors were injected postsynaptically. These observations indicate that in early UP the cAMP signaling pathway, instead of transmitting signals for the generation of LTP, gates UP through postsynaptic protein phosphatases.

AB - The role of the CAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated CAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca2+/calmodulin-mediated stimulation of postsynaptic adenylyl cyclase. The early phase of LTP produced by the same pattern of high frequency stimulation was dependent on postsynaptic cAMP. However, synaptic transmission was not increased by postsynaptic application of CAMP. Early LTP became cAMP-independent when protein phosphatase inhibitors were injected postsynaptically. These observations indicate that in early UP the cAMP signaling pathway, instead of transmitting signals for the generation of LTP, gates UP through postsynaptic protein phosphatases.

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DO - 10.1016/0896-6273(95)90018-7

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VL - 15

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JO - Neuron

JF - Neuron

IS - 6

ER -

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

Abstract

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