Postsurgical treatment of early-stage breast cancer with electronic brachytherapy: Outcomes and health-related quality of life at 1 year

Rakesh R. Patel, Peter D. Beitsch, Timothy D. Nichols, John D. Lorenzetti, James C. Wurzer, James C. Tucker, George W. Nunn, Susan J. Laduzinsky, Morris A. Kugler, Dwelvin L. Simmons, Michael S. Gilligan, Tapan Roy, Jonathon K. Foley, John P. Thropay, Mark William Odou, Bruce A. Bornstein, Elizabeth P. Tito, Manjeet Chadha, Susan K. Boolbol, Steven C. LaneJulie G. White

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

OBJECTIVES:: This multicenter registry followed up patients with early-stage breast cancer treated with breast-conserving surgery and electronic brachytherapy (EBT). This report provides 1- and 2-year updates to the initial publication. METHODS:: Patients were of age 50 years or more with invasive carcinoma or ductal carcinoma in situ, tumor size ≤3 cm, and negative surgical margins. After lumpectomy, patients received EBT in 10 fractions over 5 days (34 Gy total). RESULTS:: Of the 69 patients enrolled, 62 were evaluated at 1 year and 20 patients at 2 years after treatment. At 1 year, 28 (45.2%) patients reported adverse events that were possibly, probably, or definitely related to treatment. Most (90%) were grade 1: manageable and typical of radiation therapy. Four events were grade 2: induration/firmness (2), field contracture (1), and seroma (1). One event was grade 3: a draining fistula at the lumpectomy site due to residual effects of a breast infection at 1 month. No recurrences have been reported. Cosmetic ratings were excellent or good in 93.4% of patients at 1 year. Most patients (69%) were energetic most or all of the time. Most patients (69% to 98%) were not affected by individual symptoms of breast disease at 1 year. Generally patients who had an adverse event did not report the corresponding symptom on the quality-of-life questionnaire. CONCLUSIONS:: This registry followed up patients with early-stage breast cancer at 1 and 2 years after breast-conserving surgery and EBT. No recurrences have been reported, and adverse effects were acceptable.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume36
Issue number5
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Breast cancer
  • Electronic brachytherapy
  • Radiation therapy

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