TY - JOUR
T1 - Postoperative mometasone irrigations improve quality of life in skull base tumor patients
AU - Salmon, Mandy K.
AU - Kshirsagar, Rijul S.
AU - Eide, Jacob G.
AU - Sweis, Auddie M.
AU - Davin, Kathleen
AU - Prasad, Aman
AU - Ungerer, Heather
AU - Stevens, Elizabeth
AU - Ig-Izevbekhai, Kevin
AU - Tripathi, Siddhant
AU - Locke, Tran B.
AU - Lin, Theodore
AU - Sweis, Brian M.
AU - Kohanski, Michael A.
AU - Adappa, Nithin D.
AU - Palmer, James N.
N1 - Publisher Copyright:
© 2023 The Authors. World Journal of Otorhinolaryngology - Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.
PY - 2023/12
Y1 - 2023/12
N2 - Objectives: The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied. We quantified long-term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ESBS. Methods: Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to 2019. Data on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was collected. Preoperative, and 1-, 3-, 6-, 12-, 18-, and 24-month postoperative Sino-Nasal Outcome Test (SNOT-22) scores were assessed. Results: A total of 727 patients were assessed (53.4% males), with 479 patients in the no SI group and 248 patients in the SI group. Preoperative SNOT-22 scores did not differ significantly (P = 0.19). 1-, 3-, 6-, 12-, 18-, and 24-month post-op SNOT-22 scores did not significantly differ between groups. However, mometasone irrigations resulted in significantly lower postoperative 2-year SNOT-22 scores compared to budesonide (P < 0.01) and saline (P = 0.03). Conclusions: Though corticosteroid irrigations are routine in managing inflammatory sinus disease, their role in postoperative management after ESBS for tumors is unclear. Our findings suggest that mometasone irrigation may be effective at improving postoperative quality of life in patients after ESBS.
AB - Objectives: The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied. We quantified long-term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ESBS. Methods: Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to 2019. Data on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was collected. Preoperative, and 1-, 3-, 6-, 12-, 18-, and 24-month postoperative Sino-Nasal Outcome Test (SNOT-22) scores were assessed. Results: A total of 727 patients were assessed (53.4% males), with 479 patients in the no SI group and 248 patients in the SI group. Preoperative SNOT-22 scores did not differ significantly (P = 0.19). 1-, 3-, 6-, 12-, 18-, and 24-month post-op SNOT-22 scores did not significantly differ between groups. However, mometasone irrigations resulted in significantly lower postoperative 2-year SNOT-22 scores compared to budesonide (P < 0.01) and saline (P = 0.03). Conclusions: Though corticosteroid irrigations are routine in managing inflammatory sinus disease, their role in postoperative management after ESBS for tumors is unclear. Our findings suggest that mometasone irrigation may be effective at improving postoperative quality of life in patients after ESBS.
KW - postoperative steroid irrigations
KW - skull base tumors
UR - http://www.scopus.com/inward/record.url?scp=85159402867&partnerID=8YFLogxK
U2 - 10.1002/wjo2.99
DO - 10.1002/wjo2.99
M3 - Article
AN - SCOPUS:85159402867
SN - 2095-8811
VL - 9
SP - 314
EP - 319
JO - World Journal of Otorhinolaryngology - Head and Neck Surgery
JF - World Journal of Otorhinolaryngology - Head and Neck Surgery
IS - 4
ER -