Postoperative hypertension: A prospective, placebo-controlled, randomized, double-blind trial, with intravenous nicardipine hydrochloride

N. A. Halpern, M. Alicea, L. R. Krakoff, R. Greenstein

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Nicardipine hydrochloride, a new calcium channel blocker for intravenous use, has been compared with placebo in a prospective, randomized, double-blind trial on postoperative hypertension. Of 175 patients who signed preoperative consent, 24 (13.7%) met entry criteria. Hypertension was significantly better controlled in nicardipine-treated patients compared with those receiving placebo (93% versus 30%, p < 0.05). All the placebo failures were subsequently successfully treated with nicardipine. There were no significant complications in either group. The authors conclude that nicardipine HC1 is an effective, safe therapy for postoperative hypertension. Further studies are now indicated comparing it with other drugs currently used to treat this condition.

Original languageEnglish
Pages (from-to)992-1004
Number of pages13
JournalAngiology
Volume41
Issue number11 SUPPL.
StatePublished - 1990
Externally publishedYes

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