TY - JOUR
T1 - Postoperative cognitive dysfunction after endovascular treatments for unruptured intracranial aneurysms
T2 - A pilot study
AU - Ishii, Daizo
AU - Zanaty, Mario
AU - Roa, Jorge A.
AU - Li, Luyuan
AU - Lu, Yongjun
AU - Allan, Lauren
AU - Samaniego, Edgar A.
AU - Torner, James C.
AU - Tranel, Daniel
AU - Hasan, David M.
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2022/8
Y1 - 2022/8
N2 - Objective: Post operative cognitive dysfunction (POCD) has been widely observed after major surgery, particularly in elderly patients with general anesthesia (GA). However, a specific unanswered question is whether different approaches to anesthetic managements are associated with different cognitive outcomes after endovascular treatments for unruptured intracranial aneurysms (UIAs). The purpose of this study is to assess the correlation of POCD with GA versus monitored anesthesia care (MAC). Methods: We performed a pragmatic, prospective study to assess the association between different anesthetic approaches and POCD. We compared the pre- and post-procedural Montreal Cognitive Assessment (MoCA) scores in patients with normal cognition who underwent treatments of UIAs with various endovascular methods, using either GA or MAC. Results: A total of 23 patients with UIAs were enrolled in the study. Seven (30.4%) and sixteen (69.6%) UIAs were treated without perioperative complications under GA or MAC, respectively. There was a significant decline in the post-procedural MoCA score under GA (mean difference = 1.14; 95% confidence interval = [0.42–1.87], P < 0.01). By contrast, there was no significant difference of MoCA score between pre- and post-procedure under MAC (mean difference = 0.19; 95% confidence interval = [−0.29–0.67], P = 0.59). Conclusions: Treating UIAs using MAC was associated with a decrease in POCD as compared to GA in patients undergoing endovascular treatments for UIAs with normal cognition. Larger randomized studies are needed to confirm these findings.
AB - Objective: Post operative cognitive dysfunction (POCD) has been widely observed after major surgery, particularly in elderly patients with general anesthesia (GA). However, a specific unanswered question is whether different approaches to anesthetic managements are associated with different cognitive outcomes after endovascular treatments for unruptured intracranial aneurysms (UIAs). The purpose of this study is to assess the correlation of POCD with GA versus monitored anesthesia care (MAC). Methods: We performed a pragmatic, prospective study to assess the association between different anesthetic approaches and POCD. We compared the pre- and post-procedural Montreal Cognitive Assessment (MoCA) scores in patients with normal cognition who underwent treatments of UIAs with various endovascular methods, using either GA or MAC. Results: A total of 23 patients with UIAs were enrolled in the study. Seven (30.4%) and sixteen (69.6%) UIAs were treated without perioperative complications under GA or MAC, respectively. There was a significant decline in the post-procedural MoCA score under GA (mean difference = 1.14; 95% confidence interval = [0.42–1.87], P < 0.01). By contrast, there was no significant difference of MoCA score between pre- and post-procedure under MAC (mean difference = 0.19; 95% confidence interval = [−0.29–0.67], P = 0.59). Conclusions: Treating UIAs using MAC was associated with a decrease in POCD as compared to GA in patients undergoing endovascular treatments for UIAs with normal cognition. Larger randomized studies are needed to confirm these findings.
KW - Endovascular treatment
KW - general anesthesia
KW - intracranial aneurysm
KW - monitored anesthesia care
KW - postoperative cognitive dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85114831060&partnerID=8YFLogxK
U2 - 10.1177/15910199211039917
DO - 10.1177/15910199211039917
M3 - Article
AN - SCOPUS:85114831060
SN - 1591-0199
VL - 28
SP - 439
EP - 443
JO - Interventional Neuroradiology
JF - Interventional Neuroradiology
IS - 4
ER -