Postnatal IVIG treatment for persistent anaemia in neonate due to congenital parvovirus infection

Olivia Janssen, Jing Lin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Congenital parvovirus B19 infection is a rare but serious condition that can result in hydrops fetalis and fetal death. Due to the virus' cytotoxic effect on fetal red blood cell precursors, postnatal infection can cause a neonatal viremia and secondary pure red cell aplasia. Here, we describe a case of congenital parvovirus infection in a preterm infant complicated by hydrops fetalis and chronic anaemia that responded to postnatal treatment with intravenous immunoglobulin administered on day of life 44. After treatment, the anaemia resolved as the neonate exhibited interval increases in haemoglobin, haematocrit and reticulocyte count with no subsequent need for red blood cell transfusions.

Original languageEnglish
JournalBMJ Case Reports
Volume14
Issue number1
DOIs
StatePublished - 11 Jan 2021

Keywords

  • haematology (incl blood transfusion)
  • materno-fetal medicine
  • neonatal intensive care

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