Postmenopausal uterine bleeding due to estrogen production by gonadotropin-secreting lung tumors

Lawrence G. Smith, Sergey L. Lyubsky, Harold E. Carlson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Two postmenopausal women are described who had uterine bleeding due to hormone production by lung tumors-a large cell carcinoma in one case and a choriocarcinoma in the other. Both tumors stained positively for one or more placental peptides (human chorionic gonadotropin [hCG], placental lactogen, or pregnancy-specific β-1 glycoprotein) and both patients had extremely elevated serum levels of hCG, suggesting the tumors had some placental-like endocrine function. Clinical and hormonal data supported the concept that the uterine bleeding resulted from estrogen excess due to steroid biotransformation by the tumors.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalAmerican Journal of Medicine
Volume92
Issue number3
DOIs
StatePublished - Mar 1992
Externally publishedYes

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