TY - JOUR
T1 - Post-transplant lymphoproliferative disorder of the cervix
AU - Nagarsheth, Nimesh P.
AU - Kalir, Tamara
AU - Rahaman, Jamal
PY - 2005/4
Y1 - 2005/4
N2 - Background. Post-transplant lymphoproliferative disorder involving the female genital tract is a rare event. Case. A 67-year-old female status post orthotopic liver transplant 5 years previously for hepatitis B and sarcoidosis presented with vaginal bleeding. Endometrial biopsy revealed a high-grade malignant tumor with immunologic marker studies consistent with lymphoma. The patient underwent an exploratory laparotomy, modified radical hysterectomy, bilateral salpingo oophorectomy, bilateral selective pelvic and para-aortic lymphadenectomy, and omentectomy. Final pathology confirmed monomorphic B-cell post-transplantation lymphoproliferative disorder consistent with non-Hodgkin's B cell lymphoma confined to the endocervix and lower uterine segment. She remains recurrence free after 4 years with no adjuvant therapy. Conclusion. Post-transplant complications can present in the female reproductive organs. Gynecologic oncologists need to be aware of this disease process when treating patients for gynecologic symptoms after transplant surgery.
AB - Background. Post-transplant lymphoproliferative disorder involving the female genital tract is a rare event. Case. A 67-year-old female status post orthotopic liver transplant 5 years previously for hepatitis B and sarcoidosis presented with vaginal bleeding. Endometrial biopsy revealed a high-grade malignant tumor with immunologic marker studies consistent with lymphoma. The patient underwent an exploratory laparotomy, modified radical hysterectomy, bilateral salpingo oophorectomy, bilateral selective pelvic and para-aortic lymphadenectomy, and omentectomy. Final pathology confirmed monomorphic B-cell post-transplantation lymphoproliferative disorder consistent with non-Hodgkin's B cell lymphoma confined to the endocervix and lower uterine segment. She remains recurrence free after 4 years with no adjuvant therapy. Conclusion. Post-transplant complications can present in the female reproductive organs. Gynecologic oncologists need to be aware of this disease process when treating patients for gynecologic symptoms after transplant surgery.
KW - Cervix
KW - Epstein-Barr virus
KW - Post-transplant lymphoproliferative disorder
UR - http://www.scopus.com/inward/record.url?scp=15544384716&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2004.12.049
DO - 10.1016/j.ygyno.2004.12.049
M3 - Article
C2 - 15790475
AN - SCOPUS:15544384716
SN - 0090-8258
VL - 97
SP - 271
EP - 275
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 1
ER -