Post-transcription regulation of drug metabolic enzymes by miRNAs

Pei Wang; Xiao Tian Li; Li Rong Zhang

doi:10.3969/j.issn.1001-1978.2015.08.001

Post-transcription regulation of drug metabolic enzymes by miRNAs

Pei Wang, Xiao Tian Li, Li Rong Zhang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

microRNAs (miRNAs) are a family of short non-coding RNAs that regulate the expression of target genes by binding to complementary regions. The miRNAs expression is readily altered by drugs, carcinogens, hormones, stress or diseases, and that might lead to changes in the drug metabolism, pharmacokinetics or potency. Moreover, the evaluation of drug metabolic enzyme-related miRNAs would provide useful information for personalized medicine. This review describes the current knowledge on the post-transcription regulation of drug metabolic enzymes by miRNAs.

Original language	English
Pages (from-to)	1037-1040
Number of pages	4
Journal	Chinese Pharmacological Bulletin
Volume	31
Issue number	8
DOIs	https://doi.org/10.3969/j.issn.1001-1978.2015.08.001
State	Published - 1 Aug 2015
Externally published	Yes

Keywords

CYP450
GST
Metabolic enzymes
MiRNA
Post-transcription regulation
UGT

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10.3969/j.issn.1001-1978.2015.08.001

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AU - Li, Xiao Tian

AU - Zhang, Li Rong

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AB - microRNAs (miRNAs) are a family of short non-coding RNAs that regulate the expression of target genes by binding to complementary regions. The miRNAs expression is readily altered by drugs, carcinogens, hormones, stress or diseases, and that might lead to changes in the drug metabolism, pharmacokinetics or potency. Moreover, the evaluation of drug metabolic enzyme-related miRNAs would provide useful information for personalized medicine. This review describes the current knowledge on the post-transcription regulation of drug metabolic enzymes by miRNAs.

KW - CYP450

KW - GST

KW - Metabolic enzymes

KW - MiRNA

KW - Post-transcription regulation

KW - UGT

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JO - Chinese Pharmacological Bulletin

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ER -

Post-transcription regulation of drug metabolic enzymes by miRNAs

Abstract

Keywords

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