Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms

Linda M. Bierer; Peter J. Knott; James M. Schmeidler; Deborah B. Marin; Theresa M. Ryan; Vahram Haroutunian; Dushyant P. Purohit; Daniel P. Perl; Richard C. Mohs; Kenneth L. Davis

doi:10.1016/0165-1781(93)90062-L

Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms

Linda M. Bierer
, Peter J. Knott
, James M. Schmeidler
, Deborah B. Marin
, Theresa M. Ryan
, Vahram Haroutunian
, Dushyant P. Purohit
, Daniel P. Perl
, Richard C. Mohs
, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Psychiatry Research
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(93)90062-L
State	Published - Dec 1993

Keywords

Dementia
agitation
cognitive impairment
depression
dihydroxyphenylacetic acid
homovanillic acid
neuropathology
psychosis
temporal cortex

Access to Document

10.1016/0165-1781(93)90062-L

Cite this

@article{a03e9be5048d43428d4499bb983ab361,

title = "Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms",

abstract = "Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.",

keywords = "Dementia, agitation, cognitive impairment, depression, dihydroxyphenylacetic acid, homovanillic acid, neuropathology, psychosis, temporal cortex",

author = "Bierer, \{Linda M.\} and Knott, \{Peter J.\} and Schmeidler, \{James M.\} and Marin, \{Deborah B.\} and Ryan, \{Theresa M.\} and Vahram Haroutunian and Purohit, \{Dushyant P.\} and Perl, \{Daniel P.\} and Mohs, \{Richard C.\} and Davis, \{Kenneth L.\}",

year = "1993",

month = dec,

doi = "10.1016/0165-1781(93)90062-L",

language = "English",

volume = "49",

pages = "211--217",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Post-mortem examination of dopaminergic parameters in Alzheimer's disease

T2 - Relationship to noncognitive symptoms

AU - Bierer, Linda M.

AU - Knott, Peter J.

AU - Schmeidler, James M.

AU - Marin, Deborah B.

AU - Ryan, Theresa M.

AU - Haroutunian, Vahram

AU - Purohit, Dushyant P.

AU - Perl, Daniel P.

AU - Mohs, Richard C.

AU - Davis, Kenneth L.

PY - 1993/12

Y1 - 1993/12

N2 - Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.

AB - Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.

KW - Dementia

KW - agitation

KW - cognitive impairment

KW - depression

KW - dihydroxyphenylacetic acid

KW - homovanillic acid

KW - neuropathology

KW - psychosis

KW - temporal cortex

UR - https://www.scopus.com/pages/publications/0027769917

U2 - 10.1016/0165-1781(93)90062-L

DO - 10.1016/0165-1781(93)90062-L

M3 - Article

C2 - 8177917

AN - SCOPUS:0027769917

SN - 0165-1781

VL - 49

SP - 211

EP - 217

JO - Psychiatry Research

JF - Psychiatry Research

IS - 3

ER -

Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms

Abstract

Keywords

Access to Document

Fingerprint

Cite this